| Induced Circular-Dichroism Chirality Probes for Selective Amino Acid Detection through Screening of a Dynamic Combinatorial Library of Lanthanide Complexes. | |
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MedLine Citation:
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PMID: 22180080 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A dynamic combinatorial library of lanthanide complexes was prepared to develop induced-circular-dichroism (CD) chirality probes. It totaled 168 combinations of coordinative N-aromatic chromophores, trivalent lanthanide centers, and guest amino acids. Eu(3+) and Tb(3+) complexes prepared with quinolinecarboxylic acid were particularly effective as induced-CD chirality probes for selective alanine detection, whereas a Yb(3+) complex with terpyridine exhibited glutamine selectivity. The former two complexes highly preferred alanine to the corresponding amine, ester, amino alcohol, and carboxylic acid derivatives. As such, the present combinatorial screening of a dynamic lanthanide complex library has led to a new series of induced-CD chirality probes for specific amino acids. |
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Authors:
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Satoshi Shinoda; Keiko Terada; Hiroshi Tsukube |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-16 |
Journal Detail:
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Title: Chemistry, an Asian journal Volume: - ISSN: 1861-471X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101294643 Medline TA: Chem Asian J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Chemistry, Graduate School of Science, Osaka City University, 3-3-138, Sugimoto, Sumiyoshi-ku, Osaka 558-8585 (Japan), Fax: (+81) 6-6605-2560; JST, CREST, Osaka City University, 3-3-138, Sugimoto, Sumiyoshi-ku, Osaka 558-8585 (Japan). shinodas@sci.osaka-cu.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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