Document Detail


Indomethacin treatment in amphotericin B induced nephrogenic diabetes insipidus.
MedLine Citation:
PMID:  7865979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nephrogenic diabetes insipidus (NDI) is a serious side effect of various drugs. Elevated renal prostaglandin E2 levels have been found in patients with lithium-induced NDI and have been implicated in the pathogenesis. We report the case of a patient who developed NDI following treatment with amphotericin B. Prostaglandin levels were elevated. Indomethacin had an antidiuretic effect and normalized prostaglandin levels.
Authors:
T Höhler; G Teuber; R Wanitschke; K H Meyer zum Büschenfeld
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Clinical investigator     Volume:  72     ISSN:  0941-0198     ISO Abbreviation:  Clin Investig     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-03-28     Completed Date:  1995-03-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9207154     Medline TA:  Clin Investig     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  769-71     Citation Subset:  IM    
Affiliation:
I. Medizinische Klinik und Poliklinik, Johannes Gutenberg Universität Mainz, Germany.
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MeSH Terms
Descriptor/Qualifier:
Amphotericin B / adverse effects*
Diabetes Insipidus, Nephrogenic / chemically induced*,  drug therapy
Diuresis / drug effects
Female
Humans
Indomethacin / pharmacology,  therapeutic use*
Kidney / metabolism
Leukemia, Myelomonocytic, Acute / complications
Middle Aged
Prostaglandins / metabolism*
Tobramycin / adverse effects
Vasopressins / therapeutic use
Chemical
Reg. No./Substance:
0/Prostaglandins; 11000-17-2/Vasopressins; 1397-89-3/Amphotericin B; 32986-56-4/Tobramycin; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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