Document Detail

Indomethacin tocolysis and intraventricular hemorrhage.
MedLine Citation:
PMID:  11384697     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the association between indomethacin tocolysis and neonatal intraventricular hemorrhage. METHODS: Fifty-six preterm neonates with intraventricular hemorrhage were matched by gestational age with neonates (n = 224) without this morbidity. Maternal and neonatal charts were reviewed to ascertain the type of tocolytic exposure experienced by the neonate. Other maternal and neonatal demographic and outcome data were also abstracted. Results were analyzed using the Student t test, chi(2) analysis, and multivariable logistic regression. The number of studied subjects provided 80% power to determine if antenatal exposure to indomethacin was twice as likely among infants with intraventricular hemorrhage. RESULTS: Univariate analysis revealed that there were no significant differences between the study and control groups with respect to maternal age, parity, or betamethasone exposure. Infants with intraventricular hemorrhage were significantly more likely to be born at an earlier gestational age, a lower birth weight, after maternal chorioamnionitis, after vaginal delivery, and after exposure to either indomethacin alone or a combination of indomethacin and magnesium. Additionally, their neonatal course was significantly more likely to be complicated by sepsis and respiratory distress syndrome. In a multivariable logistic model, only gestational age, chorioamnionitis, vaginal delivery, and respiratory distress syndrome continued to be significantly associated with intraventricular hemorrhage. Indomethacin exposure, either as single-agent (adjusted odds ratio 1.3, 95% confidence interval 0.5, 3.3) or combination tocolytic therapy (adjusted odds ratio 2.0, 95% confidence interval 0.8, 4.8), was not significantly associated with intraventricular hemorrhage. CONCLUSION: Indomethacin tocolysis is not associated with an increased risk of intraventricular hemorrhage.
R D Suarez; W A Grobman; B V Parilla
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  97     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-05-31     Completed Date:  2001-06-21     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  921-5     Citation Subset:  AIM; IM    
Section of Maternal-Fetal Medicine and the Department of Obstetrics and Gynecology, Northwestern Memorial Hospital and Evanston Hospital, Northwestern University Medical School, Chicago, Illinois, USA.
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MeSH Terms
Analysis of Variance
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  adverse effects*
Case-Control Studies
Confidence Intervals
Drug Therapy, Combination
Indomethacin / administration & dosage,  adverse effects*
Infant, Newborn
Intracranial Hemorrhages / chemically induced*,  epidemiology*,  ultrasonography
Logistic Models
Magnesium / administration & dosage,  adverse effects
Obstetric Labor, Premature / prevention & control*
Odds Ratio
Pregnancy Outcome
Reference Values
Risk Factors
Tocolysis / adverse effects*,  methods
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 53-86-1/Indomethacin; 7439-95-4/Magnesium

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