Document Detail


Indomethacin reverses the microglial response to amyloid beta-protein.
MedLine Citation:
PMID:  9661994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alzheimer's disease (AD) brains display intense microglial immunoreactivity in the area of senile plaques, suggesting that amyloid beta-protein may stimulate microglial infiltration. The activated microglia may modulate an immune response in the brain. Non-steroidal anti-inflammatory drugs (NSAIDs) are candidate therapeutics for AD because their effects on immune system components may influence the course of the disease. The present study examined the effects of an NSAID (indomethacin) on amyloid beta-protein-induced microglial infiltration. Amyloid beta-protein was chronically infused into rat lateral ventricles for 2 weeks. Extracellular amyloid beta-protein deposited along the lining and diffused into the tissue surrounding the lateral ventricle. Immunocytochemical staining showed that animals receiving amyloid beta-protein exhibited dramatic microglial response when compared to vehicle-infused rats. Activated microglia surrounded immunopositive amyloid beta-protein deposits, but this response was significantly attenuated in animals receiving either concurrent i.c.v. or subcutaneous (s.c.) treatment with indomethacin. These results suggest that chronic amyloid beta-protein infusion induces the proliferation of activated microglia and that indomethacin may be an effective treatment for inhibiting microglial proliferation.
Authors:
E E Netland; J L Newton; R E Majocha; B A Tate
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurobiology of aging     Volume:  19     ISSN:  0197-4580     ISO Abbreviation:  Neurobiol. Aging     Publication Date:    1998 May-Jun
Date Detail:
Created Date:  1998-09-16     Completed Date:  1998-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-4     Citation Subset:  IM    
Affiliation:
Department of Medicine, The Miriam Hospital and Brown University School of Medicine, Providence, RI 02906, USA.
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MeSH Terms
Descriptor/Qualifier:
Amyloid beta-Protein / antagonists & inhibitors*,  pharmacology
Animals
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  pharmacology*
Brain / pathology
Brain Chemistry / drug effects
Immunohistochemistry
Indomethacin / administration & dosage,  pharmacology*
Injections, Intraventricular
Male
Microglia / drug effects*
Rats
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Anti-Inflammatory Agents, Non-Steroidal; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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