| Indomethacin and renal function in premature infants with persistent patent ductus arteriosus. | |
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MedLine Citation:
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PMID: 480039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Renal function during indomethacin treatment was studied in 12 premature infants with patent ductus arteriosus. Decreases in urinary flow rate, GFR, and CH2O by 56, 27, and 66%, respectively, occurred during Indo therapy. Urinary excretion rates of ions were also reduced: Na by 70%, Cl by 79%, K by 40%. These changes were accompanied by slight decreases in plasma sodium concentration and osmolality. Except for GFR and urinary Na and osmolality, all these functions returned to pretreatment values one to two weeks after stopping the drug. |
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Authors:
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R F Cifuentes; P M Olley; J W Balfe; I C Radde; S J Soldin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 95 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1979 Oct |
Date Detail:
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Created Date: 1979-11-29 Completed Date: 1979-11-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 583-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ductus Arteriosus, Patent
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drug therapy,
physiopathology* Glomerular Filtration Rate / drug effects Humans Indomethacin / pharmacology*, therapeutic use Infant, Newborn Infant, Premature, Diseases / drug therapy, physiopathology* Kidney / drug effects, physiopathology* |
| Chemical | |
Reg. No./Substance:
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53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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