Document Detail

Indomethacin for prevention of heterotopic ossification. A randomized controlled study in 41 hip arthroplasties.
MedLine Citation:
PMID:  8291408     Owner:  NLM     Status:  MEDLINE    
The effect of indomethacin 25 mg 3 times daily during the first 2 postoperative weeks in preventing heterotopic bone formation after cemented total hip arthroplasty was investigated in a randomized, double-blind and placebo-controlled clinical trial on 57 patients. 16 patients were secondarily excluded, leaving 19 patients in the indomethacin group and 22 patients in the placebo group. Evaluated from the 3-month radiographs, 18/19 indomethacin patients developed either no or only the milder Grade 1 ossification. In contrast, 11/22 placebo patients developed Grade 2 or 3 ossifications. Our observations favor indomethacin prophylaxis for 2 weeks in cemented arthroplasty of the hip.
P Kjaersgaard-Andersen; A Nafei; G Teichert; O Kristensen; S A Schmidt; J Keller; U Lucht
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta orthopaedica Scandinavica     Volume:  64     ISSN:  0001-6470     ISO Abbreviation:  Acta Orthop Scand     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-02-24     Completed Date:  1994-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370352     Medline TA:  Acta Orthop Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  639-42     Citation Subset:  IM    
Orthopedic Hospital, University of Aarhus, Denmark.
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MeSH Terms
Aged, 80 and over
Double-Blind Method
Hip Prosthesis*
Indomethacin / therapeutic use*
Middle Aged
Ossification, Heterotopic / prevention & control*
Postoperative Complications / prevention & control
Reg. No./Substance:

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