Document Detail

Indomethacin for post-ERCP pancreatitis prophylaxis: another attempt at the Holy Grail.
MedLine Citation:
PMID:  17489783     Owner:  NLM     Status:  MEDLINE    
Acute pancreatitis continues to be the most dreaded complication after ERCP. Various risk factors for post-ERCP pancreatitis have now been recognized including patient-related, procedure-related, and operator-related factors. Numerous attempts at finding the ideal pharmacological agent for prevention of this complication have been made but nearly all drugs evaluated have failed to demonstrate clinical efficacy. Predictably, these agents have shown promise in early single-center studies but met with disappointing results when tested in larger multicenter randomized controlled trials. As the quest for the "magic bullet" continues, selecting patients with appropriate indications for ERCP and prophylactic pancreatic duct stenting in high-risk cases appears to be the best approach to averting this complication.
Mihir S Wagh; Stuart Sherman
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Publication Detail:
Type:  Comment; Editorial    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  102     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-10     Completed Date:  2007-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  984-6     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Cholangiopancreatography, Endoscopic Retrograde / adverse effects*
Indomethacin / therapeutic use*
Pancreatitis / etiology*,  prevention & control*
Risk Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 53-86-1/Indomethacin
Comment On:
Am J Gastroenterol. 2007 May;102(5):978-83   [PMID:  17355281 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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