Document Detail

Indomethacin and pancreatic blood flow. An experimental study in pigs.
MedLine Citation:
PMID:  2239055     Owner:  NLM     Status:  MEDLINE    
Indomethacin has been reported to decrease pancreatic blood flow. The drug has been used as an analgesic in acute pancreatitis. As decreased blood flow to the pancreas may detrimentally affect the outcome of acute pancreatitis, we investigated the effects of indomethacin on blood flow in the normal porcine pancreas. Regional blood flows, with special reference to the pancreatic flow, were studied with radioactively labelled microspheres in ketamine-anesthetized pigs before and after intravenous administration of indomethacin 2 mg/kg during 10 min. A transient decrease of cardiac output was seen during the infusion. Basal pancreatic blood flow was significantly increased 10 and 30 min after administration of indomethacin. No significant changes were found in small-intestinal or renal blood flow. We conclude that indomethacin does not reduce blood flow in normal porcine pancreas.
B Hjelmqvist; H Teder; A Borgström; S Björkman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta chirurgica Scandinavica     Volume:  156     ISSN:  0001-5482     ISO Abbreviation:  Acta Chir Scand     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-12-07     Completed Date:  1990-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906530     Medline TA:  Acta Chir Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  543-7     Citation Subset:  IM    
Department of Surgery, Malmö General Hospital, Sweden.
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MeSH Terms
Cardiac Output / drug effects,  physiology
Indomethacin / pharmacology*
Pancreas / blood supply*,  drug effects
Regional Blood Flow / drug effects
Reg. No./Substance:

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