| Indomethacin and pancreatic blood flow. An experimental study in pigs. | |
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MedLine Citation:
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PMID: 2239055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Indomethacin has been reported to decrease pancreatic blood flow. The drug has been used as an analgesic in acute pancreatitis. As decreased blood flow to the pancreas may detrimentally affect the outcome of acute pancreatitis, we investigated the effects of indomethacin on blood flow in the normal porcine pancreas. Regional blood flows, with special reference to the pancreatic flow, were studied with radioactively labelled microspheres in ketamine-anesthetized pigs before and after intravenous administration of indomethacin 2 mg/kg during 10 min. A transient decrease of cardiac output was seen during the infusion. Basal pancreatic blood flow was significantly increased 10 and 30 min after administration of indomethacin. No significant changes were found in small-intestinal or renal blood flow. We conclude that indomethacin does not reduce blood flow in normal porcine pancreas. |
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Authors:
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B Hjelmqvist; H Teder; A Borgström; S Björkman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta chirurgica Scandinavica Volume: 156 ISSN: 0001-5482 ISO Abbreviation: Acta Chir Scand Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-12-07 Completed Date: 1990-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906530 Medline TA: Acta Chir Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 543-7 Citation Subset: IM |
Affiliation:
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Department of Surgery, Malmö General Hospital, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiac Output / drug effects, physiology Indomethacin / pharmacology* Microspheres Pancreas / blood supply*, drug effects Regional Blood Flow / drug effects Swine |
| Chemical | |
Reg. No./Substance:
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53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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