Document Detail

Indomethacin and ketanserin block ethchlorvynol-induced hypoxemia in dogs.
MedLine Citation:
PMID:  3096135     Owner:  NLM     Status:  MEDLINE    
Intravenous injection of ethchlorvynol (ECV) leads to hypoxemia and a permeability pulmonary edema. Whether the hypoxemia is directly attributable to the pulmonary edema or caused by release of mediators has not been explored. Three groups of dogs were studied: (1) ECV, (2) indomethacin--ECV, and (3) ketanserin--ECV. In group 1, 25 to 30 mg/kg of ECV caused a significant fall in PaO2 at 4 min (92 +/- 12.6 to 77 +/- 21 mm Hg, p less than 0.05), which persisted throughout the experiment. The P(A-a)O2 gradient widened significantly at 3 min (22 +/- 11 to 31 +/- 16.8 mm Hg, p less than 0.05) and remained abnormal for the remainder of the experiment. There was no significant fall in PaO2 in groups 2 and 3. Lung tissue water to dry weight ratio increased significantly in all groups at 60 min. Lung tissue water to dry weight ratios were normal at 10 min after ECV injection in additional groups. It was concluded that ECV causes hypoxemia, which is mediated by cyclooxygenase products and 5 hydroxytryptamine. This hypoxemia can be prevented by the administration of drugs that block these products.
J E Millen; F L Glauser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  292     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-12-05     Completed Date:  1986-12-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  AIM; IM    
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MeSH Terms
Anoxia / chemically induced*,  physiopathology,  prevention & control
Blood Pressure / drug effects
Carbon Dioxide / blood
Cardiac Output / drug effects
Indomethacin / administration & dosage,  pharmacology*
Injections, Intravenous
Ketanserin / administration & dosage,  pharmacology*
Oxygen / blood
Prostaglandin-Endoperoxide Synthases / physiology
Pulmonary Edema / chemically induced*,  physiopathology,  prevention & control
Pulmonary Wedge Pressure / drug effects
Serotonin / physiology
Reg. No./Substance:
113-18-8/Ethchlorvynol; 124-38-9/Carbon Dioxide; 50-67-9/Serotonin; 53-86-1/Indomethacin; 74050-98-9/Ketanserin; 7782-44-7/Oxygen; EC Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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