Document Detail


Indomethacin inhibits duodenal mucosal bicarbonate secretion and endogenous prostaglandin E2 output in human subjects.
MedLine Citation:
PMID:  3468819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nonsteroidal anti-inflammatory drugs are a frequent cause of gastric and duodenal mucosal injury. We examined the effect of indomethacin on duodenal mucosal bicarbonate secretion and prostaglandin output in healthy subjects. Subjects received either 50 mg of indomethacin or placebo orally 13 hours and 1 hour before study. A 4-cm segment of proximal (the duodenal bulb) or distal (10 to 14 cm beyond the pylorus) duodenum was isolated and perfused with 154 mM NaCl containing a nonabsorbable marker. In the proximal duodenum indomethacin reduced both basal and acid-stimulated bicarbonate secretion by approximately 65% (p less than 0.01); in the distal duodenum indomethacin decreased basal and acid-stimulated bicarbonate output by approximately 45% (p less than 0.01). Oral indomethacin inhibited basal and acid-stimulated duodenal prostaglandin E2 output in both the proximal and distal duodenum. We conclude that, by decreasing duodenal mucosal bicarbonate production and prostaglandin output in humans, oral indomethacin, in two doses of 50 mg each, impairs an important duodenal defense mechanism.
Authors:
J A Selling; D L Hogan; A Aly; M A Koss; J I Isenberg
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of internal medicine     Volume:  106     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-03-19     Completed Date:  1987-03-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  368-71     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Administration, Topical
Adult
Bicarbonates / secretion*
Dinoprostone
Duodenum / drug effects
Female
Humans
Hydrogen-Ion Concentration
Indomethacin / pharmacology*
Intestinal Mucosa / drug effects*,  secretion
Male
Prostaglandins E / metabolism*
Grant Support
ID/Acronym/Agency:
AM 07202/AM/NIADDK NIH HHS; AM 33491-02/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Bicarbonates; 0/Prostaglandins E; 363-24-6/Dinoprostone; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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