Document Detail

Indomethacin and fetal ductus arteriosus: complete closure after cessation of prolonged therapeutic course.
MedLine Citation:
PMID:  8894629     Owner:  NLM     Status:  MEDLINE    
Indomethacin is a very effective tocolytic agent. However, concern about its possible constrictive effect on fetal ductus arteriosus has limited the use of this medication in pregnancy. A 29-year-old woman was treated with indomethacin at 27 weeks of gestation for preterm labor and polyhydramnios. She received a dose of 75 mg/day for 5 weeks. At 35 weeks of gestation, she had a cesarean delivery due to fetal distress, and a hydropic baby was delivered. The infant died shortly after. Nonimmune hydrops fetalis and closed ductus arteriosus were the only pathological findings at autopsy. In utero, irreversible, complete closure of the ductus arteriosus is very rare. In the case presented, prolonged use of indomethacin during pregnancy was associated with complete closure of the ductus arteriosus that developed most probably after discontinuation of therapy. This case emphasizes the need for frequent fetal echocardiography examinations during as well as after maternal indomethacin treatment.
Y Ben-David; M Hallak; A Rotschild; Y Sorokin; R Auslender; H Abramovici
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  11     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    1996 Sep-Oct
Date Detail:
Created Date:  1997-02-13     Completed Date:  1997-02-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  341-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
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MeSH Terms
Constriction, Pathologic / chemically induced
Ductus Arteriosus* / pathology
Hydrops Fetalis / etiology
Indomethacin / administration & dosage,  adverse effects*,  therapeutic use
Obstetric Labor, Premature / drug therapy*
Polyhydramnios / drug therapy
Reg. No./Substance:

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