| Indomethacin disposition and indomethacin-induced platelet dysfunction in premature infants. | |
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MedLine Citation:
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PMID: 641216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Indomethacin failed to produce permanent ductal closure in any of four premature infants with patent ductus arteriosus to whom the drug was given. Indomethacin half-lives measured in two premature infants were 21 and 24 hours, respectively, much longer than in full-term newborns or adults. Platelet function, as measured by platelet aggregation, was grossly abnormal for two to four days after indomethacin administration, normal values returning only by the ninth and tenth days. Gastrointestinal bleeding and transient renal dysfunction occurred in one infant. Measurement of plasma indomethacin concentrations in sick, low-birthweight infants could help guide indomethacin dose and dosage interval, prevent drug accumulation, and reduce toxicity. Further studies of potential toxicity seem to be indicated before instituting widespread indomethacin administration for ductal closure in premature infants. |
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Authors:
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Z Friedman; V Whitman; M J Maisels; W Berman; K H Marks; E S Vesell |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 18 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1978 May-Jun |
Date Detail:
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Created Date: 1978-06-17 Completed Date: 1978-06-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 272-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Platelet Disorders
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blood,
chemically induced* Blood Proteins / metabolism Ductus Arteriosus, Patent / blood, drug therapy* Female Half-Life Humans Indomethacin / adverse effects, blood*, therapeutic use Infant, Newborn* Infant, Newborn, Diseases / blood, chemically induced* Male Platelet Aggregation / drug effects Protein Binding Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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