Document Detail

Indomethacin disposition and indomethacin-induced platelet dysfunction in premature infants.
MedLine Citation:
PMID:  641216     Owner:  NLM     Status:  MEDLINE    
Indomethacin failed to produce permanent ductal closure in any of four premature infants with patent ductus arteriosus to whom the drug was given. Indomethacin half-lives measured in two premature infants were 21 and 24 hours, respectively, much longer than in full-term newborns or adults. Platelet function, as measured by platelet aggregation, was grossly abnormal for two to four days after indomethacin administration, normal values returning only by the ninth and tenth days. Gastrointestinal bleeding and transient renal dysfunction occurred in one infant. Measurement of plasma indomethacin concentrations in sick, low-birthweight infants could help guide indomethacin dose and dosage interval, prevent drug accumulation, and reduce toxicity. Further studies of potential toxicity seem to be indicated before instituting widespread indomethacin administration for ductal closure in premature infants.
Z Friedman; V Whitman; M J Maisels; W Berman; K H Marks; E S Vesell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  18     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:    1978 May-Jun
Date Detail:
Created Date:  1978-06-17     Completed Date:  1978-06-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  272-9     Citation Subset:  IM    
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MeSH Terms
Blood Platelet Disorders / blood,  chemically induced*
Blood Proteins / metabolism
Ductus Arteriosus, Patent / blood,  drug therapy*
Indomethacin / adverse effects,  blood*,  therapeutic use
Infant, Newborn*
Infant, Newborn, Diseases / blood,  chemically induced*
Platelet Aggregation / drug effects
Protein Binding
Time Factors
Reg. No./Substance:
0/Blood Proteins; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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