Document Detail

Indomethacin for closure of patent ductus arteriosus in prematures.
MedLine Citation:
PMID:  7039927     Owner:  NLM     Status:  MEDLINE    
A controlled, double blind trial of indomethacin versus placebo was conducted in prematures of birth weight less than 1750 g, with a murmur of patent ductus arteriosus (PDA). The dose of indomethacin was 0.2 mg/kg for 2 doses, orally, 24 hours apart. Forty-seven patients entered the trial. Twenty-four received indomethacin and 12 of these met the criteria for response; 23 received the placebo and two met the criteria for response (p less than 0.01). Subsequent surgical ligation for symptomatic PDA was required in 13 of 23 in the placebo group and 4 of 24 in the indomethacin group (p less than 0.01). When administered early, indomethacin is moderately effective in closing PDA in premature infants.
M D Mullett; T W Croghan; D Z Myerberg; J M Krall; W A Neal
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical pediatrics     Volume:  21     ISSN:  0009-9228     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-06-14     Completed Date:  1982-06-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-20     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Double-Blind Method
Ductus Arteriosus, Patent / drug therapy*
Enterocolitis, Pseudomembranous / chemically induced
Gastrointestinal Hemorrhage / chemically induced
Indomethacin / adverse effects,  therapeutic use*
Infant, Newborn
Infant, Premature, Diseases / drug therapy*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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