| Indomethacin by intravenous infusion in ureteral colic. A multicentre study. | |
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MedLine Citation:
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PMID: 7163787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a multicentre study the analgetic effect of indomethacin in ureteral colic was analyzed. Indomethacin, which inhibits the synthesis of prostaglandin, was given by intravenous infusion in a dose of 50 mg. The study comprised 198 patients with 252 attacks of ureteral colic. Satisfactory relief of pain was obtained in 212 attacks (84%). No serious side effects of indomethacin were observed. The pain recurred within four hours in only 15 patients (7%), in 12 of them during a diagnostic intravenous pyelography. The relief of pain may be explained by reduced glomerular filtration pressure and/or diminished urinary excretion, causing rapid fall in the renal pelvic pressure and in the tension of the pelvi-ureteral wall. A low extracellular volume of fluid in a patient with ureteral colic may be essential for analgetic action of indomethacin. |
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Authors:
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J G Sjödin; D Holmlund |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of urology and nephrology Volume: 16 ISSN: 0036-5599 ISO Abbreviation: Scand. J. Urol. Nephrol. Publication Date: 1982 |
Date Detail:
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Created Date: 1983-04-15 Completed Date: 1983-04-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0114501 Medline TA: Scand J Urol Nephrol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 221-5 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Pressure / drug effects Colic / drug therapy* Female Humans Indomethacin / administration & dosage, adverse effects, therapeutic use* Infusions, Parenteral Kidney Pelvis / physiopathology Male Middle Aged Pressure Ureteral Diseases / drug therapy* |
| Chemical | |
Reg. No./Substance:
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53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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