Document Detail

Indomethacin by intravenous infusion in ureteral colic. A multicentre study.
MedLine Citation:
PMID:  7163787     Owner:  NLM     Status:  MEDLINE    
In a multicentre study the analgetic effect of indomethacin in ureteral colic was analyzed. Indomethacin, which inhibits the synthesis of prostaglandin, was given by intravenous infusion in a dose of 50 mg. The study comprised 198 patients with 252 attacks of ureteral colic. Satisfactory relief of pain was obtained in 212 attacks (84%). No serious side effects of indomethacin were observed. The pain recurred within four hours in only 15 patients (7%), in 12 of them during a diagnostic intravenous pyelography. The relief of pain may be explained by reduced glomerular filtration pressure and/or diminished urinary excretion, causing rapid fall in the renal pelvic pressure and in the tension of the pelvi-ureteral wall. A low extracellular volume of fluid in a patient with ureteral colic may be essential for analgetic action of indomethacin.
J G Sjödin; D Holmlund
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of urology and nephrology     Volume:  16     ISSN:  0036-5599     ISO Abbreviation:  Scand. J. Urol. Nephrol.     Publication Date:  1982  
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0114501     Medline TA:  Scand J Urol Nephrol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  221-5     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Colic / drug therapy*
Indomethacin / administration & dosage,  adverse effects,  therapeutic use*
Infusions, Parenteral
Kidney Pelvis / physiopathology
Middle Aged
Ureteral Diseases / drug therapy*
Reg. No./Substance:

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