Document Detail

Indolic tryptophan metabolism in uraemia.
MedLine Citation:
PMID:  935125     Owner:  NLM     Status:  MEDLINE    
Tryptophan and some indolic metabolites were studied in urine, plasma and dialysate of uraemic patients using thin-layer- and high-pressure liquid chromatography. Some new metabolites: indole-3-carboxylic acid, indole-3-carbaldehyde, indolelactic acid and N-acetyltryptophan were detected. Levels of the latter two metabolites in urine, dialysate and especially plasma suggest increased transamination of tryptophan and a possible defect in renal amino acid acylase in uraemia.
D J Byrd; H W Berthold; K F Trefz; W Kochen; G Gilli; K Schärer; H W Schüler; H W Asbach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association     Volume:  12     ISSN:  0071-2736     ISO Abbreviation:  Proc Eur Dial Transplant Assoc     Publication Date:  1976  
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  0355210     Medline TA:  Proc Eur Dial Transplant Assoc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  347-54     Citation Subset:  IM    
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MeSH Terms
Aldehydes / metabolism
Carboxylic Acids / metabolism
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Indoles / metabolism*
Kidney / enzymology
Kidney Failure, Chronic / metabolism
Tryptophan / analogs & derivatives,  metabolism*
Uremia / metabolism*
Reg. No./Substance:
0/Aldehydes; 0/Carboxylic Acids; 0/Indoles; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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