| Indolent aspergillus arthritis complicating fludarabine-based non-myeloablative stem cell transplantation. | |
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MedLine Citation:
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PMID: 11319599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fungal arthritis and osteomyelitis are rare and documented mainly in immunocompromised or neutropenic patients. Patients receiving therapeutic immunosuppression for organ transplants have also reported to suffer from aspergillus osteoarthritis. We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation. Both were suffering from acute and chronic GVHD and treated with heavy immunosuppression including steroids and cyclosporine. Interestingly in one of our patients, the arthritis was almost asymptomatic and did not spread to other organs. Heavy pre- and post-transplant immunosuppression is a major risk factor for invasive fungal infection, which can involve remote organs and manifest in an indolent and atypical manner. |
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Authors:
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S Panigrahi; A Nagler; R Or; D G Wolf; S Slavin; M Y Shapira |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Bone marrow transplantation Volume: 27 ISSN: 0268-3369 ISO Abbreviation: Bone Marrow Transplant. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-04-25 Completed Date: 2001-09-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: England |
Other Details:
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Languages: eng Pagination: 659-61 Citation Subset: IM |
Affiliation:
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Department of Bone Marrow Transplantation, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arthritis / microbiology* Aspergillosis* Graft vs Host Disease / drug therapy Hematopoietic Stem Cell Transplantation / adverse effects* Humans Immunosuppressive Agents / administration & dosage, adverse effects Knee Joint / pathology Male Middle Aged Vidarabine / administration & dosage, adverse effects*, analogs & derivatives |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 21679-14-1/fludarabine; 5536-17-4/Vidarabine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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