Document Detail

Indolent aspergillus arthritis complicating fludarabine-based non-myeloablative stem cell transplantation.
MedLine Citation:
PMID:  11319599     Owner:  NLM     Status:  MEDLINE    
Fungal arthritis and osteomyelitis are rare and documented mainly in immunocompromised or neutropenic patients. Patients receiving therapeutic immunosuppression for organ transplants have also reported to suffer from aspergillus osteoarthritis. We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation. Both were suffering from acute and chronic GVHD and treated with heavy immunosuppression including steroids and cyclosporine. Interestingly in one of our patients, the arthritis was almost asymptomatic and did not spread to other organs. Heavy pre- and post-transplant immunosuppression is a major risk factor for invasive fungal infection, which can involve remote organs and manifest in an indolent and atypical manner.
S Panigrahi; A Nagler; R Or; D G Wolf; S Slavin; M Y Shapira
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  27     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-25     Completed Date:  2001-09-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  659-61     Citation Subset:  IM    
Department of Bone Marrow Transplantation, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel.
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MeSH Terms
Arthritis / microbiology*
Graft vs Host Disease / drug therapy
Hematopoietic Stem Cell Transplantation / adverse effects*
Immunosuppressive Agents / administration & dosage,  adverse effects
Knee Joint / pathology
Middle Aged
Vidarabine / administration & dosage,  adverse effects*,  analogs & derivatives
Reg. No./Substance:
0/Immunosuppressive Agents; 21679-14-1/fludarabine; 5536-17-4/Vidarabine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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