Document Detail


Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy.
MedLine Citation:
PMID:  12385839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pharmacologic inhibition of indoleamine 2,3-dioxygenase (IDO) activity during murine pregnancy results in maternal T-cell-mediated rejection of allogeneic but not syngeneic conceptuses. Increased risk of allogeneic pregnancy failure induced by exposure to IDO inhibitor is strongly correlated with maternal C3 deposition at the maternal-fetal interface. Here we review evidence that cells expressing IDO contribute to immunosuppression by inhibiting T-cell responses to tumor antigens and tissue allografts, as well as fetal tissues.
Authors:
Andrew L Mellor; Phillip Chandler; Geon Kook Lee; Theodore Johnson; Derin B Keskin; Jeffrey Lee; David H Munn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  57     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:    2002 Oct-Nov
Date Detail:
Created Date:  2002-10-18     Completed Date:  2003-05-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  143-50     Citation Subset:  IM    
Affiliation:
Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA. amellor@mail.mcg.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Enzyme Inhibitors / pharmacology
Female
Humans
Immune Tolerance* / drug effects
Indoleamine-Pyrrole 2,3,-Dioxygenase
Inflammation / enzymology,  immunology
Maternal-Fetal Exchange / drug effects,  immunology*
Mice
Neoplasms / enzymology,  immunology
Pregnancy
T-Lymphocytes / immunology
Transplantation Immunology
Tryptophan Oxygenase / antagonists & inhibitors,  immunology*
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; EC 1.13.11.11/Tryptophan Oxygenase; EC 1.13.11.42/Indoleamine-Pyrrole 2,3,-Dioxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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