Document Detail


Indoleamine 2,3-dioxygenase (IDO) activity is lower in atopic than in non-atopic individuals and is enhanced by environmental factors protecting from atopy.
MedLine Citation:
PMID:  15992929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tryptophan catabolism activated by the indoleamine 2,3-dioxygenase (EC 1.13.11.42) (IDO) enzyme in antigen presenting cells has a central role in induction of mechanisms suppressing T cell activation or clonal expansion. There is evidence suggesting that IDO activity is mainly upregulated by typical Th1-differentiating signals such as interferon-gamma and bacterial lipopolysaccharide (LPS). Therefore, we hypothesized that IDO activity would be lower in a Th2-associated disease such as atopy and that it would be higher in the presence of environmental factors known to favor Th1 differentiation. Here we show that this was the case. Concentrations of tryptophan (trp) and kynurenine (kyn), the main metabolite, were determined by reverse phase liquid chromatography from serum samples of a cohort of 392 non-asthmatic individual of whom 149 were atopics (one or more positive skin test when tested with a panel of 22 allergens). Kyn/trp ratio, as an indicator of IDO activity, was significantly lower in atopic than in non-atopic individuals. The cohort was stratified according to two known atopy-protecting factors, presence of antibodies against Helicobacter pylori or anamnestic information about childhood on a farm environment. As expected, IDO activity was significantly higher in their presence than absence.
Authors:
Annika Raitala; Jussi Karjalainen; Simo S Oja; Timo U Kosunen; Mikko Hurme
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-29
Journal Detail:
Title:  Molecular immunology     Volume:  43     ISSN:  0161-5890     ISO Abbreviation:  Mol. Immunol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2005-12-20     Completed Date:  2006-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905289     Medline TA:  Mol Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1054-6     Citation Subset:  IM    
Affiliation:
University of Tampere Medical School, Tampere, Finland. annika.raitala@uta.fi
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Bacterial / blood
Cohort Studies
Down-Regulation
Environment
Female
Helicobacter pylori / immunology
Humans
Hypersensitivity, Immediate / enzymology*,  immunology
Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism*
Kynurenine / blood
Male
Th2 Cells / immunology*
Tryptophan / blood
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 343-65-7/Kynurenine; 73-22-3/Tryptophan; EC 1.13.11.42/Indoleamine-Pyrrole 2,3,-Dioxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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