Document Detail

Indole alkaloids and other constituents of Rauwolfia serpentina.
MedLine Citation:
PMID:  15974606     Owner:  NLM     Status:  MEDLINE    
From the dried roots of Rauwolfia serpentina were isolated five new indole alkaloids, N(b)-methylajmaline (1), N(b)-methylisoajmaline (2), 3-hydroxysarpagine (3), yohimbinic acid (4), isorauhimbinic acid (5), a new iridoid glucoside, 7-epiloganin (6), and a new sucrose derivative, 6'-O-(3,4,5-trimethoxybenzoyl)glomeratose A (7), together with 20 known compounds. The structures of the new compounds were determined by spectroscopic and chemical means. The inhibitory activities of the selected alkaloids on topoisomerase I and II and their cytotoxicity against the human promyelocytic leukemia (HL-60) cell lines were assessed.
Atsuko Itoh; Tomoko Kumashiro; Machiko Yamaguchi; Naotaka Nagakura; Yoshiyuki Mizushina; Toyoyuki Nishi; Takao Tanahashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of natural products     Volume:  68     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-24     Completed Date:  2005-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  848-52     Citation Subset:  IM    
Kobe Pharmaceutical University, Higashinada-ku, Japan.
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MeSH Terms
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification*,  pharmacology
Drug Screening Assays, Antitumor
HL-60 Cells
Indole Alkaloids / chemistry,  isolation & purification*,  pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Rauwolfia / chemistry*
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Indole Alkaloids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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