| Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters. | |
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MedLine Citation:
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PMID: 6791164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dihydroteleocidin B, which is a derivative of teleocidin from Streptomyces, showed potent tumor-promoting activity in vivo when painted on mouse skin. Although the chemical structure of dihydroteleocidin B is entirely different from those of phorbol esters, the tumor-promoting activity of dihydroteleocidin B was found to be comparable to that of 12-O-tetradecanoylphorbol 13-acetate (TPA) in vivo. Teleocidin from Streptomyces and lyngbyatoxin A and debromoaplysiatoxin from the marine blue-green alga Lyngbya majuscula induced ornithine decarboxylase activity when painted on mouse skin, their effects being similar to those of dihyroteleocidin B and TPA. 13-cis-Retinoic acid inhibited this ornithine decarboxylase induction when painted on the skin 1 hr before these natural products. These three compounds produced adhesion of human promyelocytic leukemia cells (HL-60) to the flasks and inhibited differentiation of Friend erythroleukemia cells induced by dimethyl sulfoxide. The in vitro biological potencies of teleocidin and lyngbyatoxin A were almost as great as those of dihydroteleocidin B and TPA, but that of debromoaplysiatoxin was much weaker. |
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Authors:
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H Fujiki; M Mori; M Nakayasu; M Terada; T Sugimura; R E Moore |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 78 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1981 Jun |
Date Detail:
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Created Date: 1981-10-29 Completed Date: 1981-10-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3872-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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9,10-Dimethyl-1,2-benzanthracene Alkaloids* Animals Carcinogens* Cocarcinogenesis* Dermotoxins Enzyme Induction / drug effects Female Irritants Lyngbya Toxins* Marine Toxins Mice Neoplasms, Experimental / chemically induced Ornithine Decarboxylase / biosynthesis Skin Neoplasms / chemically induced Structure-Activity Relationship |
| Grant Support | |
ID/Acronym/Agency:
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CA12632-06/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Alkaloids; 0/Carcinogens; 0/Dermotoxins; 0/Irritants; 0/Lyngbya Toxins; 0/Marine Toxins; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 70497-14-2/lyngbyatoxin A; 7491-76-1/dihydroteleocidin B; 78474-55-2/teleocidin; EC 4.1.1.17/Ornithine Decarboxylase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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