Document Detail


Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters.
MedLine Citation:
PMID:  6791164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dihydroteleocidin B, which is a derivative of teleocidin from Streptomyces, showed potent tumor-promoting activity in vivo when painted on mouse skin. Although the chemical structure of dihydroteleocidin B is entirely different from those of phorbol esters, the tumor-promoting activity of dihydroteleocidin B was found to be comparable to that of 12-O-tetradecanoylphorbol 13-acetate (TPA) in vivo. Teleocidin from Streptomyces and lyngbyatoxin A and debromoaplysiatoxin from the marine blue-green alga Lyngbya majuscula induced ornithine decarboxylase activity when painted on mouse skin, their effects being similar to those of dihyroteleocidin B and TPA. 13-cis-Retinoic acid inhibited this ornithine decarboxylase induction when painted on the skin 1 hr before these natural products. These three compounds produced adhesion of human promyelocytic leukemia cells (HL-60) to the flasks and inhibited differentiation of Friend erythroleukemia cells induced by dimethyl sulfoxide. The in vitro biological potencies of teleocidin and lyngbyatoxin A were almost as great as those of dihydroteleocidin B and TPA, but that of debromoaplysiatoxin was much weaker.
Authors:
H Fujiki; M Mori; M Nakayasu; M Terada; T Sugimura; R E Moore
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  78     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1981 Jun 
Date Detail:
Created Date:  1981-10-29     Completed Date:  1981-10-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3872-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
9,10-Dimethyl-1,2-benzanthracene
Alkaloids*
Animals
Carcinogens*
Cocarcinogenesis*
Dermotoxins
Enzyme Induction / drug effects
Female
Irritants
Lyngbya Toxins*
Marine Toxins
Mice
Neoplasms, Experimental / chemically induced
Ornithine Decarboxylase / biosynthesis
Skin Neoplasms / chemically induced
Structure-Activity Relationship
Grant Support
ID/Acronym/Agency:
CA12632-06/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Carcinogens; 0/Dermotoxins; 0/Irritants; 0/Lyngbya Toxins; 0/Marine Toxins; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 70497-14-2/lyngbyatoxin A; 7491-76-1/dihydroteleocidin B; 78474-55-2/teleocidin; EC 4.1.1.17/Ornithine Decarboxylase
Comments/Corrections

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