Document Detail


Indole acts as an extracellular cue regulating gene expression in Vibrio cholerae.
MedLine Citation:
PMID:  19329638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Indole has been proposed to act as an extracellular signal molecule influencing biofilm formation in a range of bacteria. For this study, the role of indole in Vibrio cholerae biofilm formation was examined. It was shown that indole activates genes involved in vibrio polysaccharide (VPS) production, which is essential for V. cholerae biofilm formation. In addition to activating these genes, it was determined using microarrays that indole influences the expression of many other genes, including those involved in motility, protozoan grazing resistance, iron utilization, and ion transport. A transposon mutagenesis screen revealed additional components of the indole-VPS regulatory circuitry. The indole signaling cascade includes the DksA protein along with known regulators of VPS production, VpsR and CdgA. A working model is presented in which global control of gene expression by indole is coordinated through sigma(54) and associated transcriptional regulators.
Authors:
Ryan S Mueller; Sinem Beyhan; Simran G Saini; Fitnat H Yildiz; Douglas H Bartlett
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-03-27
Journal Detail:
Title:  Journal of bacteriology     Volume:  191     ISSN:  1098-5530     ISO Abbreviation:  J. Bacteriol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-14     Completed Date:  2009-06-02     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3504-16     Citation Subset:  IM    
Affiliation:
Marine Biology Research Division, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92037, USA.
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MeSH Terms
Descriptor/Qualifier:
Bacterial Proteins / genetics,  physiology
Biofilms / drug effects,  growth & development
DNA Transposable Elements / genetics,  physiology
Gene Expression Regulation, Bacterial / drug effects*,  genetics*
Green Fluorescent Proteins / genetics,  metabolism
Indoles / pharmacology*
Models, Biological
Mutagenesis
Mutation
Transcription, Genetic / drug effects,  genetics
Tryptophanase / genetics
Vibrio cholerae / drug effects,  genetics
Grant Support
ID/Acronym/Agency:
AI46600-02/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/DNA Transposable Elements; 0/Indoles; 147336-22-9/Green Fluorescent Proteins; 8724FJW4M5/indole; EC 4.1.99.1/Tryptophanase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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