Document Detail


Indole Alkaloids and Quassinoids from the Stems of Brucea mollis.
MedLine Citation:
PMID:  22070654     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Seven new indole alkaloids, bruceollines H-N (1-7), three new quassinoids, yadanziolides T-V (10-12), and four known analogues, bruceolline E (8), bruceolline F (9), bruceine D (13), and yadanziolide B (14), were isolated from an ethanol extract of the stems of Brucea mollis. The absolute configurations of compounds 2 and 5 were determined by comparison of their experimental and calculated ECD spectra. The absolute configuration of the known compound 9 was determined by using Mo(2)(OAc)(4)-induced CD analysis for the first time. Compounds 10, 13, and 14 exhibited cytotoxic activities with IC(50) values of 3.00-5.81 μM.
Authors:
Hui Chen; Jian Bai; Zhen-Feng Fang; Shi-Shan Yu; Shuang-Gang Ma; Song Xu; Yong Li; Jing Qu; Jin-Hong Ren; Li Li; Yi-Kang Si; Xiao-Guang Chen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-9
Journal Detail:
Title:  Journal of natural products     Volume:  -     ISSN:  1520-6025     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
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