| Indole Alkaloids and Quassinoids from the Stems of Brucea mollis. | |
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MedLine Citation:
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PMID: 22070654 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Seven new indole alkaloids, bruceollines H-N (1-7), three new quassinoids, yadanziolides T-V (10-12), and four known analogues, bruceolline E (8), bruceolline F (9), bruceine D (13), and yadanziolide B (14), were isolated from an ethanol extract of the stems of Brucea mollis. The absolute configurations of compounds 2 and 5 were determined by comparison of their experimental and calculated ECD spectra. The absolute configuration of the known compound 9 was determined by using Mo(2)(OAc)(4)-induced CD analysis for the first time. Compounds 10, 13, and 14 exhibited cytotoxic activities with IC(50) values of 3.00-5.81 μM. |
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Authors:
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Hui Chen; Jian Bai; Zhen-Feng Fang; Shi-Shan Yu; Shuang-Gang Ma; Song Xu; Yong Li; Jing Qu; Jin-Hong Ren; Li Li; Yi-Kang Si; Xiao-Guang Chen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-9 |
Journal Detail:
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Title: Journal of natural products Volume: - ISSN: 1520-6025 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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