| Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): Central amino acid linker and right-hand-side SAR studies. | |
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MedLine Citation:
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PMID: 21592789 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this part 2, new indole 5-carboxamide Thumb Pocket 1 inhibitors of HCV NS5B polymerase are described. Structure-activity relationships (SAR) were explored at the central amino acid linker position and the right-hand-side of the molecule in an attempt to identify molecules with a balanced overall profile of potency (EC(50)<100nM), physicochemical properties and ADME characteristics. |
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Authors:
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Pierre L Beaulieu; Catherine Chabot; Jianmin Duan; Michel Garneau; James Gillard; Eric Jolicoeur; Martin Poirier; Marc-André Poupart; Timothy A Stammers; George Kukolj; Youla S Tsantrizos |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-24 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: - ISSN: 1464-3405 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-5-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Chemistry, Boehringer Ingelheim (Canada) Ltd, Research and Development, 2100 Cunard Street, Laval (Québec), Canada H7S 2G5. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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