Document Detail

Individualized treatment of type 2 diabetes mellitus using noninsulin agents: clinical considerations for the primary care physician.
MedLine Citation:
PMID:  22913898     Owner:  NLM     Status:  In-Data-Review    
Background: The outcomes associated with some therapies may be potentially influenced by specific patient characteristics. Individualized therapy is an effort to achieve optimal health outcomes for a patient by selecting drugs known to be beneficial in persons with specific attributes or disease characteristics. With a broad literature base spanning several different medication classes, there is increasing potential for individualization of therapy in the treatment of type 2 diabetes mellitus. Purpose: To review the literature for data that support associations between patient characteristics and outcomes resulting from treatment with antihyperglycemic medications. Results and Conclusions: Review of the medical literature suggests that 3 general considerations are important for individualized therapy: disease pathophysiology, modifiers of treatment response, and risks of nonadherence. Currently, there are limited data demonstrating that nongenetic patient characteristics modify treatment response, while a number of genetic polymorphisms are known to influence the pharmacology of certain antidiabetic agents. The available literature includes evaluation of key nongenetic factors, such as age, race, body mass index, patient sex, disease duration, and baseline glycated hemoglobin level. Of these, glycated hemoglobin level is the best-described laboratory value correlated with treatment response. Recent literature has brought to physicians' attention the more practical aspects of treatment that can influence outcomes, mainly those associated with medication adherence. These include out-of-pocket costs, tolerability/side effects, and the complexity of daily treatment regimens.
Nancy J V Bohannon
Related Documents :
18564678 - Management of enteroviral conjunctivitis outbreaks in the singapore military in 2005.
10203948 - Defense mechanisms in alexithymia.
22348258 - An internet survey on self-reported food allergy in greece: clinical aspects and lack o...
2052848 - Cystic echinococcosis in the xinjiang/uygur autonomous region, people's republic of chi...
576328 - Multiphasic screening. case-finding tool in a teaching hospital medical clinic.
14498938 - Medicine as discursive resource: legitimation in the work narratives of midwives.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medicine     Volume:  124     ISSN:  1941-9260     ISO Abbreviation:  Postgrad Med     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401147     Medline TA:  Postgrad Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  95-108     Citation Subset:  AIM; IM    
St. Luke's Hospital, San Francisco, CA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Diabetes pharmacotherapy in 2012: considerations in medication selection.
Next Document:  Controversies in prediabetes: do we have a diagnosis?