Document Detail

Individualization of drug dosage during long-term treatment with phenprocoumon (Falithrom).
MedLine Citation:
PMID:  689796     Owner:  NLM     Status:  MEDLINE    
Pharmacokinetic studies were carried out with 3H-phenprocoumon (3H-PPC) during long-term treatment with phenprocoumon (PPC, Falithrom) in 10 female and male patients with thromboembolic diseases. Additionally, 12 mg 3H-PPC were administered per os to 6 male volunteers. Half-life and pattern of urine metabolites were measured and compared with those in patients. The radioactivity decreased independently of the total PPC plasma concentration, which was estimated fluorometrically. An exponential regression with a high coefficient of determination was found between the mean maintenance dose (PPC) and the area under plasma concentration curve of radioactivity. This procedure is considered to be a method to improve long-term treatment with PPC.
K O Haustein; M Richter; G Vogel; E Mittag
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology and biopharmacy     Volume:  16     ISSN:  0340-0026     ISO Abbreviation:  Int J Clin Pharmacol Biopharm     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-11-18     Completed Date:  1978-11-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505527     Medline TA:  Int J Clin Pharmacol Biopharm     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  372-6     Citation Subset:  IM    
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MeSH Terms
4-Hydroxycoumarins / administration & dosage*
Middle Aged
Phenprocoumon / administration & dosage*,  blood
Prothrombin Time
Time Factors
Reg. No./Substance:
0/4-Hydroxycoumarins; 435-97-2/Phenprocoumon

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