Document Detail

Individual variability in cardiovascular disease risk factor responses to low-fat and low-saturated-fat diets in men: body mass index, adiposity, and insulin resistance predict changes in LDL cholesterol.
MedLine Citation:
PMID:  16280425     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although reductions in total and saturated fat consumption are recommended to reduce the risk of cardiovascular disease, individual variability in plasma lipid responses exists. OBJECTIVE: Our aim was to determine the effect of adiposity and insulin resistance on the lipoprotein response to diets lower in total and saturated fat than the average American diet (AAD). DESIGN: A randomized, double-blind, 3-period crossover controlled feeding design was used to examine the effects on plasma lipids of 3 diets that differed in total fat: the AAD [designed to contain 38% fat and 14% saturated fatty acids (SFAs)], the Step I diet (30% fat with 9% SFAs), and the Step II diet (25% fat with 6% SFAs). The diets were fed for 6 wk each to 86 free-living, healthy men aged 22-64 y at levels designed to maintain weight. RESULTS: Compared with the AAD, the Step I and Step II diets lowered LDL cholesterol by 6.8% and 11.7%, lowered HDL cholesterol by 7.5% and 11.2%, and raised triacylglycerols by 14.3% and 16.2%, respectively. The Step II diet response showed significant positive correlations between changes in both LDL cholesterol and the ratio of total to HDL cholesterol and baseline percentage body fat, body mass index, and insulin. These associations were largely due to smaller reductions in LDL cholesterol with increasing percentage body fat, body mass index, or insulin concentrations. Subdivision of the study population showed that the participants in the upper one-half of fasting insulin concentrations averaged only 57% of the reduction in LDL cholesterol with the Step II diet of the participants in the lower half. CONCLUSION: Persons who are insulin resistant respond less favorably to Step II diets than do those who are insulin sensitive.
Michael Lefevre; Catherine M Champagne; Richard T Tulley; Jennifer C Rood; Marlene M Most
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  82     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-10     Completed Date:  2005-12-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  957-63; quiz 1145-6     Citation Subset:  AIM; IM    
Division of Functional Foods Research, Pennington Biomedical Research Center, Baton Rouge, LA 70808-4124, USA.
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MeSH Terms
Adipose Tissue / metabolism*
Body Mass Index
Cardiovascular Diseases / blood,  diet therapy*,  epidemiology
Cholesterol, HDL / blood
Cholesterol, LDL / blood*
Cross-Over Studies
Diet, Fat-Restricted*
Dietary Fats / administration & dosage
Double-Blind Method
Insulin / blood,  metabolism
Insulin Resistance*
Middle Aged
Obesity / blood,  diet therapy,  physiopathology*
Risk Factors
Triglycerides / blood
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dietary Fats; 0/Triglycerides; 11061-68-0/Insulin
Comment In:
Am J Clin Nutr. 2005 Nov;82(5):919-20   [PMID:  16280419 ]
Am J Clin Nutr. 2006 Apr;83(4):921; author reply 921-2   [PMID:  16600949 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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