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Individual and synergistic effects of sniffing frequency and flow rate on olfactory bulb activity.
MedLine Citation:
PMID:  21900510     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Is faster or stronger sniffing important for the olfactory system? Odorant molecules are captured by sniffing. The features of sniffing constrain both the temporality and intensity of the input to the olfactory structures. In this context, it is clear that variations in both the sniff frequency and flow rate have a major impact on the activation of olfactory structures. However, the question of how frequency and flow rate individually or synergistically impact bulbar output has not been answered. We have addressed this question using multiple experimental approaches. In double-tracheotomized anesthetized rats, we recorded both the bulbar local field potential and mitral/tufted cells activities when the sampling flow rate and frequency were independently controlled. We found that a tradeoff between the sampling frequency and the flow rate could maintain olfactory bulb sampling-related rhythmicity and that only an increase in flow rate could induce a faster odor-evoked response. Local field potential and sniffing were recorded in awake rats. We found that sampling-related rhythmicity was maintained during high-frequency sniffing. Furthermore, we observed that the co-variation between the frequency and flow rate, which was necessary for the tradeoff seen in the anesthetized preparations, also occurred in awake animals. Our study shows that the sampling frequency and flow rate can act either independently or synergistically on bulbar output to shape the neuronal message. The system likely takes advantage of this flexibility to adapt sniffing strategies to animal behavior. Our study provides additional support for the idea that sniffing and olfaction function in an integrated manner.
Authors:
Emmanuelle Courtiol; Chloé Hegoburu; Philippe Litaudon; Samuel Garcia; Nicolas Fourcaud-Trocmé; Nathalie Buonviso
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-7
Journal Detail:
Title:  Journal of neurophysiology     Volume:  -     ISSN:  1522-1598     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Centre de Recherche en Neurosciences de Lyon, CNRS UMR 5292, INSERM U 1028, UCBL.
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