Document Detail

Individual responses to novelty are associated with differences in behavioral and neurochemical profiles.
MedLine Citation:
PMID:  18036673     Owner:  NLM     Status:  MEDLINE    
Experimental animals can be differentiated on the basis of their horizontal or vertical activity to high responders (HR) and low responders (LR) upon exposure to a novel environment. These individual differences have been associated with behavioral and neurobiological differences in a number of experimental procedures used for studying sensitivity to psychostimulants, anxiety, depression, and cognitive function. In the present study, we differentiated the rats to HR and LR based on their vertical activity upon exposure to a novel environment. Additionally, we ascertained whether HR and LR rats differ in a battery of tests such as passive avoidance (PA), object recognition (OR), and the water-maze (WM) that provide indices for cognitive function and the forced swim test (FST), an animal model of affective responsivity and antidepressant-like activity. Potential differences in neurochemical indices between the two phenotypes were also examined. HR rats displayed impaired non-spatial object recognition memory, but enhanced spatial performance, as compared to LR rats. FST induced "depressive-like" symptoms in both phenotypes that were differently manifested in HR versus LR rats. Neurochemical findings revealed distinct differences in serotonergic and dopaminergic activity in the striatum and the prefrontal cortex of HR as compared to LR rats. The above results show that HR and LR rats exhibit important differences in a battery of tests related to cognitive performance or affective responsivity, which may be associated with differences in certain neurobiological parameters.
K Antoniou; G Papathanasiou; E Papalexi; T Hyphantis; G G Nomikos; C Spyraki; Z Papadopoulou-Daifoti
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-22
Journal Detail:
Title:  Behavioural brain research     Volume:  187     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-01-18     Completed Date:  2008-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  462-72     Citation Subset:  IM    
Department of Pharmacology, Medical School, University of Ioannina, 45110 Ioannina, Greece.
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MeSH Terms
Analysis of Variance
Avoidance Learning / physiology
Depression / metabolism
Dopamine / metabolism*
Exploratory Behavior / physiology*
Maze Learning / physiology*
Memory / physiology
Motor Activity / physiology*
Neostriatum / metabolism
Prefrontal Cortex / metabolism
Rats, Wistar
Recognition (Psychology) / physiology*
Serotonin / metabolism*
Reg. No./Substance:

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