| Individual regulation of different hepatocellular functions during sepsis. | |
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MedLine Citation:
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PMID: 1518425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to test the hypothesis that different hepatocellular functions are regulated individually during sepsis. This was done by simultaneously measuring bile production, release of liver transaminases, and synthesis of secreted proteins in perfused livers from control and septic rats. Sepsis was induced by cecal ligation and puncture (CLP); control rats were sham-operated. After 16 hours, livers were perfused in situ, and bile flow, synthesis rates of albumin and alpha 1-acid glycoprotein (a major acute-phase protein in rats), and release of glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) into perfusate were determined. Within the same livers, sepsis resulted in a 54% increase in the synthesis of alpha 1-acid glycoprotein and approximately 30% inhibition of albumin synthesis concomitant with 50% lower bile flow. The concentrations of GOT and GPT in the perfusate increased slightly during the experiments, both when control and septic livers were perfused. The maintained tissue levels of adenosine triphosphate (ATP) and the uptake of Evans blue dye by less than 1% of the hepatocytes, although a late test of viability, suggest that both control and septic livers remained viable during perfusion. The results are consistent with the concept that different hepatocellular functions are individually regulated during sepsis. Thus, impairment of certain hepatocellular functions does not necessarily imply generalized liver failure. |
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Authors:
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D von Allmen; P O Hasselgren; T Higashiguchi; J E Fischer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 41 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-10-08 Completed Date: 1992-10-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 961-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Cincinnati Medical Center, Cincinnati 45267-0558. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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analysis,
metabolism Alanine Transaminase / blood Albumins / metabolism Animals Aspartate Aminotransferases / blood Bacterial Infections / blood, metabolism*, physiopathology* Bile / metabolism Cecum / surgery Ligation Liver / metabolism, pathology, physiopathology* Liver Diseases / metabolism, pathology, physiopathology* Male Orosomucoid / metabolism Rats Rats, Inbred Strains Time Factors Transaminases / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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1R01 DK40644/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Orosomucoid; 56-65-5/Adenosine Triphosphate; EC 2.6.1.-/Transaminases; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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