Document Detail

Individual patient meta-analysis of exercise training effects on systemic brain natriuretic peptide expression in heart failure.
MedLine Citation:
PMID:  21543459     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Brain natriuretic peptide (BNP) predicts exercise performance and exercise training may modulate BNP and its N-terminal portion (NT-pro-BNP), we therefore conducted an individual patient analysis of exercise training effects on BNP and NT-pro-BNP.
AIMS: To use an individual patient meta-analysis to relate changes in BNP, NT-pro-BNP, and peak VO(2); to link these changes to volume parameters of exercise training programmes (intensity etc.); and to identify patient characteristics likely to lead to greater improvements in BNP, NT-pro-BNP, and peak VO(2).
DESIGN: Individual patient meta-analysis.
METHODS: A systematic search was conducted of Medline (Ovid),, Cochrane Central Register of Controlled Trials, and CINAHL (until July 2008) to identify randomized controlled trials of aerobic and/or resistance exercise training in systolic heart failure patients measuring BNP and/or NT-pro-BNP. Primary outcome measures were change in BNP, NT-pro-BNP, and peak VO2. Subanalyses were conducted to identify (1) patient groups that benefit most and (2) exercise programme parameters enhancing favourable changes in primary outcome measures.
RESULTS: Ten randomized controlled studies measuring BNP or NT-pro-BNP met eligibility criteria, authors provided individual patient data for 565 patients (313 exercise and 252 controls). Exercise training had favourable effects on BNP (-28.3%, p < 0.0001), NT-pro-BNP (-37.4%, p = < 0.0001), and peak VO(2) (17.8%, p < 0.0001). The analysis showed a significant change in primary outcome measures; moreover, change in BNP (r = -0.31, p < 0.0001) and NT-pro-BNP (r = -0.22, p < 0.0001) were correlated with peak VO(2) change.
CONCLUSION: Exercise training has favourable effects on BNP, NT-pro-BNP, and peak VO(2) in heart failure patients and BNP/NT-pro-BNP changes were correlated with peak VO(2) changes.
N A Smart; T Meyer; J A Butterfield; S C Faddy; C Passino; G Malfatto; S Jonsdottir; F Sarullo; U Wisloff; C Vigorito; F Giallauria
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review     Date:  2011-05-04
Journal Detail:
Title:  European journal of preventive cardiology     Volume:  19     ISSN:  2047-4881     ISO Abbreviation:  Eur J Prev Cardiol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-22     Completed Date:  2012-09-19     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101564430     Medline TA:  Eur J Prev Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  428-35     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Biological Markers / blood
Exercise Therapy*
Exercise Tolerance
Heart Failure / blood,  physiopathology,  rehabilitation*
Middle Aged
Natriuretic Peptide, Brain / blood*
Oxygen Consumption
Peptide Fragments / blood
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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