Document Detail

Individual organ contributions to the decrease in whole-body Vo2 with isoflurane.
MedLine Citation:
PMID:  1111369     Owner:  NLM     Status:  MEDLINE    
The present study was designed to determine whether there were differebnces between the effects of isoflurane and halothane on canine whole-body Vo2 and myocardial, splanchnic, renal, and skelatal muscle Vo2's were determined at isoflurane concentrations equivilent to those used in a previous study with holothane. With increases in isoflurane, whole-body Vo2 decreased progressively. As with halothane, the major comdial Vo2 that was related to a reduction in cardiac output and arterial blood pressure; contributions from other organs were minor. No significant difference between the effects of isoflurane and halothane on whole-body or individual organ Vo2's was found. These finding support the view that anesthetic agents are no general metabolic depressants and that observed changed in whole-body Vo2 reflect the su-mated changes in individual argan Vo2's occasioned by an anesthetic-induced change in organ function and metabolic requirements.
R A Theye; J D Michenfelder
Related Documents :
7270949 - Epinephrine-induced arrhythmias and cardiovascular function after verapamil during halo...
3993319 - Halothane-relaxant anaesthesia in elderly patients.
11176089 - S(+)-ketamine increases muscle sympathetic activity and maintains the neural response t...
20450279 - Surface area-volume relationships for the mastoid air cell system and tympanum in adult...
11000669 - Comparison of inhalation induction with 2%, 4%, 6%, and 8% sevoflurane in nitrous oxide...
9706929 - Incidence and time course of cardiovascular side effects during spinal anesthesia after...
6679859 - Effects of increased systemic blood pressure on the tissue fluid pressure threshold of ...
14693309 - Once-daily fixed-combination irbesartan 300 mg/ hydrochlorothiazide 25 mg and circadian...
18075519 - Structural and functional arterial properties in patients with obstructive sleep apnoea...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  42     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-04-08     Completed Date:  1975-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  35-40     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthetics / pharmacology*
Blood Pressure / drug effects
Ethers / pharmacology*
Halothane / pharmacology
Heart / physiology
Heart Rate / drug effects
Heart Ventricles / drug effects
Hydrocarbons, Fluorinated / pharmacology
Kidney / metabolism
Muscles / metabolism
Myocardium / metabolism
Oxygen Consumption / drug effects*
Regional Blood Flow / drug effects
Reg. No./Substance:
0/Anesthetics; 0/Ethers; 0/Hydrocarbons, Fluorinated; 151-67-7/Halothane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of morphine-nitrous oxide anesthesia on cerebral autoregulation.
Next Document:  Effects of succinylcholine and d-tubocurarine on epinephrine-induced arrhythmias during halothane an...