Document Detail

Individual organ contributions to the decrease in whole-body Vo2 with isoflurane.
MedLine Citation:
PMID:  1111369     Owner:  NLM     Status:  MEDLINE    
The present study was designed to determine whether there were differebnces between the effects of isoflurane and halothane on canine whole-body Vo2 and myocardial, splanchnic, renal, and skelatal muscle Vo2's were determined at isoflurane concentrations equivilent to those used in a previous study with holothane. With increases in isoflurane, whole-body Vo2 decreased progressively. As with halothane, the major comdial Vo2 that was related to a reduction in cardiac output and arterial blood pressure; contributions from other organs were minor. No significant difference between the effects of isoflurane and halothane on whole-body or individual organ Vo2's was found. These finding support the view that anesthetic agents are no general metabolic depressants and that observed changed in whole-body Vo2 reflect the su-mated changes in individual argan Vo2's occasioned by an anesthetic-induced change in organ function and metabolic requirements.
R A Theye; J D Michenfelder
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  42     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-04-08     Completed Date:  1975-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  35-40     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthetics / pharmacology*
Blood Pressure / drug effects
Ethers / pharmacology*
Halothane / pharmacology
Heart / physiology
Heart Rate / drug effects
Heart Ventricles / drug effects
Hydrocarbons, Fluorinated / pharmacology
Kidney / metabolism
Muscles / metabolism
Myocardium / metabolism
Oxygen Consumption / drug effects*
Regional Blood Flow / drug effects
Reg. No./Substance:
0/Anesthetics; 0/Ethers; 0/Hydrocarbons, Fluorinated; 151-67-7/Halothane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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