Document Detail


Individual measurements of angiotensin II concentrations in aqueous humor of the eye.
MedLine Citation:
PMID:  7711476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The presence of constituents of the renin-angiotensin system (RAS) in ocular tissues and fluids suggests this system is involved in ocular physiology. Angiotensin II (AngII) is the main biological effector of the system, so we measured AngII in plasma and in aqueous humor of the anterior ocular chamber of patients undergoing cataract extraction. Untreated normotensive patients were compared with arterial hypertensive patients taking either diuretics which stimulate the RAS or angiotensin converting enzyme (ACE) inhibitors which reduce the production of AngII. Plasma levels of AngII were higher in patients on diuretics (5.46 +/- 1.04 fmol/ml; mean +/- SEM) than in untreated cataract patients (2.28 +/- 0.32 fmol/ml, p < 0.02), and were very low with ACE inhibitors (0.51 +/- 0.18 fmol/ml). In aqueous humor, AngII was measurable in 7 of 11 patients on diuretics (median 1.1 fmol/ml), and in 6 of 16 normotensive patients (median < 0.55 fmol/ml), but not in aqueous humor of 4 patients receiving enalapril or captopril. These results demonstrate the presence of AngII in the eye but do not exclude either its sequestration in the eye or local production. The possibility of individual measurements of intraocular AngII will permit more precise determination of its role in future studies.
Authors:
R Osusky; J Nussberger; C Amstutz; J Flammer; H R Brunner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of ophthalmology     Volume:  4     ISSN:  1120-6721     ISO Abbreviation:  Eur J Ophthalmol     Publication Date:    1994 Oct-Dec
Date Detail:
Created Date:  1995-05-17     Completed Date:  1995-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9110772     Medline TA:  Eur J Ophthalmol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  228-33     Citation Subset:  IM    
Affiliation:
University Eye Hospital, Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Angiotensin II / analysis*
Aqueous Humor / chemistry*
Cataract / blood,  complications
Cataract Extraction
Chromatography, High Pressure Liquid
Diuretics / therapeutic use
Enalapril / therapeutic use
Female
Humans
Hypertension / blood,  complications,  drug therapy
Male
Middle Aged
Renin-Angiotensin System / physiology
Chemical
Reg. No./Substance:
0/Diuretics; 11128-99-7/Angiotensin II; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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