Document Detail

Individual fatty acid effects on plasma lipids and lipoproteins: human studies.
MedLine Citation:
PMID:  9129503     Owner:  NLM     Status:  MEDLINE    
The purpose of this review is to summarize our current understanding of the cholesterolemic effects of individual fatty acids. Although historically there has been great interest in the fatty acid classes, it has been only recently that emphasis has shifted to individual fatty acids. Consequently, and in conjunction with the methodologic challenges inherent in studying individual fatty acids, our database is relatively modest. Nonetheless, it is clear that saturated fatty acids are hypercholesterolemic and that unsaturated fatty acids elicit a hypocholesterolemic effect compared with saturated fatty acids. The question at hand is, What are the relative cholesterolemic effects of the major saturated and unsaturated fatty acids in the diet? On the basis of a limited number of well-controlled studies, it appears that myristic acid is the most potent saturated fatty acid. Of the saturated fatty acids, stearic acid is uniquely different in that it appears to be a neutral fatty acid. Monounsaturated fatty acids appear to exert a neutral effect or to be mildly hypocholesterolemic. trans Fatty acids elicit effects that are intermediate to those of the hypercholesterolemic saturated fatty acids and the cis-monounsaturated and cis-polyunsaturated fatty acids. Polyunsaturated fatty acids elicit the most potent hypocholesterolemic effects. Studies are needed to establish the potency with which each fatty acid affects plasma total and lipoprotein cholesterol concentrations as well as the mechanisms that account for their markedly different effects. This information will be useful in making dietary recommendations for individual fatty acids that may further reduce risk of chronic diseases in the United States.
P M Kris-Etherton; S Yu
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  65     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-05-22     Completed Date:  1997-05-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1628S-1644S     Citation Subset:  AIM; IM    
Department of Nutrition, Pennsylvania State University, University Park 16802, USA.
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MeSH Terms
Cholesterol, LDL / blood
Controlled Clinical Trials as Topic
Dietary Fats / pharmacology,  standards
Fatty Acids / chemistry,  classification,  pharmacology*
Lipids / blood*
Lipoproteins / blood*
Models, Biological
Predictive Value of Tests
Regression Analysis
Reg. No./Substance:
0/Cholesterol, LDL; 0/Dietary Fats; 0/Fatty Acids; 0/Lipids; 0/Lipoproteins

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