Document Detail

Individual effects of dietary saturated fatty acids and fish oil on plasma lipids and lipoproteins in normal men.
MedLine Citation:
PMID:  8480678     Owner:  NLM     Status:  MEDLINE    
Fish ingestion is associated with lower mortality from coronary heart disease (CHD). However, in some Western populations whose diets are rich in saturated fatty acids (SFAs), CHD mortality is consistently high despite high fish consumption. To study this paradox, we fed six healthy men diets with two amounts of SFA (5% and 19% of energy) that also differed in total fat (25% and 39% of energy). Each fat amount was given with and without n-3 fatty acids (FAs) (2% of energy) for 3 wk. On both the low and high SFA diets the presence of n-3 FAs significantly lowered plasma total cholesterol, very-low-density-lipoprotein cholesterol, (high-density-lipoprotein cholesterol (HDL-C), total triglyceride, and very-low-density-lipoprotein triglyceride. Compared with the high SFA diet, the low SFA diet decreased total cholesterol, low-density-lipoprotein cholesterol, and HDL-C. No interaction of SFA and n-3 FA was found. These results indicate that dietary SFAs and n-3 FAs have independent mechanisms of actions on the plasma lipids and lipoproteins. Optimal plasma lipids were produced by the diet low in SFA and high in n-3 FA.
A Nordöy; L F Hatcher; D L Ullmann; W E Connor
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  57     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-05-27     Completed Date:  1993-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  634-9     Citation Subset:  AIM; IM    
Department of Medicine, Oregon Health Sciences University, Portland.
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MeSH Terms
Dietary Fats / metabolism,  pharmacology*
Fatty Acids / metabolism,  pharmacology*
Fatty Acids, Omega-3 / metabolism,  pharmacology
Fish Oils / metabolism,  pharmacology*
Lipids / blood*
Lipoproteins / blood
Middle Aged
Plant Oils / metabolism,  pharmacology
Grant Support
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Lipids; 0/Lipoproteins; 0/Plant Oils; 8001-25-0/olive oil

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