| Individual differences in responses to the first cigarette following overnight abstinence in regular smokers. | |
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MedLine Citation:
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PMID: 11260809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We utilized cluster analysis to identify individual differences in response to the initial effects of smoking following overnight abstinence among 183 regular smokers. Participants smoked three cigarettes (1 mg nicotine, spaced 30 min apart) in standardized fashion and completed questionnaires about their subjective responses to each cigarette. Heart rate was monitored throughout the procedure. Participants were grouped into two clusters based on their reported subjective effects and heart rate changes to the first cigarette. Clusters differed in terms of greater increases in heart rate, reports of dizziness, sweating, unpleasantness, nausea, and buzzing sensations in one group compared to the other group. The smokers showing increased responses developed greater acute tolerance to the effects of smoking subsequent cigarettes on subjective negative effects and heart rate, and experienced greater negative affect after quitting. These results are partially consistent with a nicotine sensitivity interpretation or a tolerance model of the effects of initial smoking. |
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Authors:
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R Niaura; W G Shadel; M G Goldstein; K E Hutchinson; D B Abrams |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco Volume: 3 ISSN: 1462-2203 ISO Abbreviation: Nicotine Tob. Res. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-22 Completed Date: 2001-08-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9815751 Medline TA: Nicotine Tob Res Country: England |
Other Details:
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Languages: eng Pagination: 37-44 Citation Subset: IM |
Affiliation:
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Center for Behavioral and Preventive Medicine, Brown University and the Miriam Hospital, 164 Summit Avenue, Providence, RI 02906, USA. Raymond_Niaura@brown.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Affect Cluster Analysis Female Heart Rate / physiology Humans Male Nicotine / adverse effects*, blood Questionnaires Severity of Illness Index Smoking* Smoking Cessation* Substance Withdrawal Syndrome / diagnosis, etiology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL32318/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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