| Individual differences in reactivity to the rewarding/aversive properties of drugs: assessment by taste and place conditioning. | |
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MedLine Citation:
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PMID: 8866948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of individual differences in the strength of conditioned taste avoidance (CTA) to predict strength of place conditioning produced by the same drug was assessed. In Phase 1, rats were assigned to High CTA and Low CTA groups on the basis of their intake of saccharin solution previously paired with morphine, amphetamine, lithium, or fenfluramine. In Phase 2, the rats received place conditioning training with the same drug used during Phase 1. The rats that displayed the strongest amphetamine-induced CTA also displayed the strongest amphetamine-induced place preference, suggesting that a common mechanism mediates both effects. On the other hand, the strength of the CTA was unrelated to the strength of the place preference or place aversion produced by morphine, lithium, or fenfluramine. |
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Authors:
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S D Turenne; C Miles; L A Parker; S Siegel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 53 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1997-01-15 Completed Date: 1997-01-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 511-6 Citation Subset: IM |
Affiliation:
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Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amphetamine
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pharmacology Animals Conditioning (Psychology) / drug effects* Fenfluramine / pharmacology Lithium / pharmacology Male Morphine / pharmacology* Rats Rats, Sprague-Dawley Reward Task Performance and Analysis |
| Chemical | |
Reg. No./Substance:
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300-62-9/Amphetamine; 458-24-2/Fenfluramine; 57-27-2/Morphine; 7439-93-2/Lithium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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