Document Detail

Individual differences in maternal response to immune challenge predict offspring behavior: contribution of environmental factors.
MedLine Citation:
PMID:  21255612     Owner:  NLM     Status:  MEDLINE    
Maternal infection during pregnancy elevates risk for schizophrenia and related disorders in offspring. Converging evidence suggests the maternal inflammatory response mediates the interaction between maternal infection, altered brain development, and behavioral outcome. The extent to which individual differences in the maternal response to immune challenge influence the development of these abnormalities is unknown. The present study investigated the impact of individual differences in maternal response to the viral mimic polyinosinic:polycytidylic acid (poly I:C) on offspring behavior. We observed significant variability in body weight alterations of pregnant rats induced by administration of poly I:C on gestational day 14. Furthermore, the presence or absence of maternal weight loss predicted MK-801 and amphetamine stimulated locomotor abnormalities in offspring. MK-801 stimulated locomotion was altered in offspring of all poly I:C treated dams; however, the presence or absence of maternal weight loss resulted in decreased and modestly increased locomotion, respectively. Adult offspring of poly I:C treated dams that lost weight exhibited significantly decreased amphetamine stimulated locomotion, while offspring of poly I:C treated dams without weight loss performed similarly to vehicle controls. Social isolation and increased maternal age predicted weight loss in response to poly I:C but not vehicle injection. In combination, these data identify environmental factors associated with the maternal response to immune challenge and functional outcome of offspring exposed to maternal immune activation.
Stefanie L Bronson; Rebecca Ahlbrand; Paul S Horn; Joseph R Kern; Neil M Richtand
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-01-19
Journal Detail:
Title:  Behavioural brain research     Volume:  220     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-03-25     Completed Date:  2011-07-15     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  55-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Age Factors
Amphetamine / pharmacology
Analysis of Variance
Animals, Newborn
Antiviral Agents / administration & dosage
Behavior, Animal / drug effects,  physiology*
Body Weight / immunology
Central Nervous System Stimulants / pharmacology
Dizocilpine Maleate / pharmacology
Excitatory Amino Acid Antagonists / pharmacology
Locomotion* / drug effects
Poly I-C / administration & dosage
Predictive Value of Tests
Prenatal Exposure Delayed Effects / immunology*
Rats, Sprague-Dawley
Weight Gain / drug effects,  immunology
Weight Loss / drug effects
Grant Support
R21 MH083192/MH/NIMH NIH HHS; R21 MH083192-01A1/MH/NIMH NIH HHS; R21MH083192-01/MH/NIMH NIH HHS
Reg. No./Substance:
0/Antiviral Agents; 0/Central Nervous System Stimulants; 0/Excitatory Amino Acid Antagonists; 24939-03-5/Poly I-C; 6LR8C1B66Q/Dizocilpine Maleate; CK833KGX7E/Amphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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