| Individual differences in maternal response to immune challenge predict offspring behavior: contribution of environmental factors. | |
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MedLine Citation:
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PMID: 21255612 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal infection during pregnancy elevates risk for schizophrenia and related disorders in offspring. Converging evidence suggests the maternal inflammatory response mediates the interaction between maternal infection, altered brain development, and behavioral outcome. The extent to which individual differences in the maternal response to immune challenge influence the development of these abnormalities is unknown. The present study investigated the impact of individual differences in maternal response to the viral mimic polyinosinic:polycytidylic acid (poly I:C) on offspring behavior. We observed significant variability in body weight alterations of pregnant rats induced by administration of poly I:C on gestational day 14. Furthermore, the presence or absence of maternal weight loss predicted MK-801 and amphetamine stimulated locomotor abnormalities in offspring. MK-801 stimulated locomotion was altered in offspring of all poly I:C treated dams; however, the presence or absence of maternal weight loss resulted in decreased and modestly increased locomotion, respectively. Adult offspring of poly I:C treated dams that lost weight exhibited significantly decreased amphetamine stimulated locomotion, while offspring of poly I:C treated dams without weight loss performed similarly to vehicle controls. Social isolation and increased maternal age predicted weight loss in response to poly I:C but not vehicle injection. In combination, these data identify environmental factors associated with the maternal response to immune challenge and functional outcome of offspring exposed to maternal immune activation. |
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Authors:
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Stefanie L Bronson; Rebecca Ahlbrand; Paul S Horn; Joseph R Kern; Neil M Richtand |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-01-19 |
Journal Detail:
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Title: Behavioural brain research Volume: 220 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-03-25 Completed Date: 2011-07-15 Revised Date: 2012-02-20 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 55-64 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA. bronsose@mail.uc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Amphetamine / pharmacology Analysis of Variance Animals Animals, Newborn Antiviral Agents / administration & dosage Behavior, Animal / drug effects, physiology* Body Weight / immunology Central Nervous System Stimulants / pharmacology Dizocilpine Maleate / pharmacology Excitatory Amino Acid Antagonists / pharmacology Female Individuality* Locomotion* / drug effects Male Poly I-C / administration & dosage Predictive Value of Tests Pregnancy Prenatal Exposure Delayed Effects / immunology* Rats Rats, Sprague-Dawley Weight Gain / drug effects, immunology Weight Loss / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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R21 MH083192-01A1/MH/NIMH NIH HHS; R21MH083192-01/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Central Nervous System Stimulants; 0/Excitatory Amino Acid Antagonists; 24939-03-5/Poly I-C; 300-62-9/Amphetamine; 77086-22-7/Dizocilpine Maleate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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