Document Detail

Individual differences in cerebral metabolic patterns during pharmacotherapy in obsessive-compulsive disorder: a multiple regression/discriminant analysis of positron emission tomographic data.
MedLine Citation:
PMID:  8292684     Owner:  NLM     Status:  MEDLINE    
A multiple regression/discriminant analysis of positron emission tomographic cerebral metabolic (rCMRglc) data in 10 obsessive-compulsive disorder (OCD) patients before and during pharmacotherapy was carried out to see if rCMRglc interdependencies distinguished OCD patients from controls. Before therapy, a discriminant function reflecting parietal, sensorimotor, and midbrain rCMRglc interdependencies correctly classified eight (80%) of the 10 patients as OCD; after therapy, six (70%) were classified as controls, most of whom were responders. Before therapy, rCMRglc interdependencies involving basal ganglia, thalamus, limbic, and sensory and association cortical regions distinguished 67% of patients who clinically responded to drug (RESP, n = 6) and 75% of patients who did not (NRESP, n = 4) from controls. After therapy, all RESP were classified as controls; classification of NRESP remained unchanged. The results suggest the conjunctive utility of this method to assess individual differences in rCMRglc during pharmacotherapy, and to explore the neurobiology of OCD.
N P Azari; P Pietrini; B Horwitz; K D Pettigrew; H L Leonard; J L Rapoport; M B Schapiro; S E Swedo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  34     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-03-03     Completed Date:  1994-03-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  798-809     Citation Subset:  IM    
Laboratory of Neurosciences, National Institute of Aging/NIH, Bethesda, MD 20892.
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MeSH Terms
Brain / drug effects,  metabolism*,  radionuclide imaging
Clomipramine / therapeutic use*
Discriminant Analysis
Fluoxetine / therapeutic use*
Middle Aged
Obsessive-Compulsive Disorder / drug therapy,  metabolism,  radionuclide imaging*
Regression Analysis
Time Factors
Tomography, Emission-Computed
Reg. No./Substance:
303-49-1/Clomipramine; 54910-89-3/Fluoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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