Document Detail


Individual differences in the attribution of incentive salience to a reward-related cue: influence on cocaine sensitization.
MedLine Citation:
PMID:  17719099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When a discrete cue (a "sign") is presented repeatedly in anticipation of a food reward the cue can become imbued with incentive salience, leading some animals to approach and engage it, a phenomenon known as "sign-tracking" (the animals are sign-trackers; STs). In contrast, other animals do not approach the cue, but upon cue presentation go to the location where food will be delivered (the goal). These animals are known as goal-trackers (GTs). It has been hypothesized that individuals who attribute excessive incentive salience to reward-related cues may be especially vulnerable to develop compulsive behavioral disorders, including addiction. We were interested, therefore, in whether individual differences in the propensity to sign-track are associated with differences in responsivity to cocaine. Using an autoshaping procedure in which lever (conditioned stimulus) presentation was immediately followed by the response-independent delivery of a food pellet (unconditioned stimulus), rats were first characterized as STs or GTs and subsequently studied for the acute psychomotor response to cocaine and the propensity for cocaine-induced psychomotor sensitization. We found that GTs were more sensitive than STs to the acute locomotor activating effects of cocaine, but STs showed a greater propensity for psychomotor sensitization upon repeated treatment. These data suggest that individual differences in the tendency to attribute incentive salience to a discrete reward-related cue, and to approach and engage it, are associated with susceptibility to a form of cocaine-induced plasticity that may contribute to the development of addiction.
Authors:
Shelly B Flagel; Stanley J Watson; Huda Akil; Terry E Robinson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-07-21
Journal Detail:
Title:  Behavioural brain research     Volume:  186     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-02-12     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  48-56     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetitive Behavior / drug effects,  physiology
Association Learning / drug effects,  physiology
Behavior, Addictive / metabolism
Behavior, Animal / drug effects*,  physiology
Cocaine / pharmacology*
Conditioning, Classical / drug effects
Cues
Dopamine / metabolism
Dopamine Uptake Inhibitors / pharmacology*
Individuality
Logistic Models
Male
Motivation*
Psychomotor Performance / drug effects,  physiology
Rats
Rats, Sprague-Dawley
Reward*
Statistics, Nonparametric
Grant Support
ID/Acronym/Agency:
P01 DA021633/DA/NIDA NIH HHS; R01 DA013386/DA/NIDA NIH HHS; R01 DA013386/DA/NIDA NIH HHS; R01 DA013386-05/DA/NIDA NIH HHS; R37 DA004294/DA/NIDA NIH HHS; R37 DA004294-20/DA/NIDA NIH HHS; R37 DA04294/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; I5Y540LHVR/Cocaine; VTD58H1Z2X/Dopamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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