Document Detail


Individual and combined genotoxic response of boric acid and aflatoxin B1 in Escherichia coli PQ37.
MedLine Citation:
PMID:  9487415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The genotoxic potentials of boric acid in Escherichia coli PQ37 was assessed along in the presence of aflatoxin B1 using SOS chromotest. Boric acid induced beta-galactosidase synthesis on the tester bacteria both on the presence and absence of S9 activation mixture. Therefore, the inorganic acid may not require metabolic activation to be genotoxic for this bacteria. When present together with aflatoxin B1 in the assay medium, boric acid increased the degree of beta-galactosidase synthesis induced by the maximal inducing concentration of aflatoxin B1 before the toxin's activation. However, the degree of enzyme synthesis induced was significantly decreased when boric acid was present after aflatoxin activation. This suggests that boric acid may not interfere with nor block the expoxidation of aflatoxin B1. It may however interact with the expoxide thereby inhibiting its activity. Boric acid may be a genotoxin and could possibly act as a syngenotoxic and/or a cogenotoxic agent.
Authors:
O A Odunola
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  East African medical journal     Volume:  74     ISSN:  0012-835X     ISO Abbreviation:  East Afr Med J     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1998-03-13     Completed Date:  1998-03-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372766     Medline TA:  East Afr Med J     Country:  KENYA    
Other Details:
Languages:  eng     Pagination:  499-502     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria.
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MeSH Terms
Descriptor/Qualifier:
Aflatoxin B1 / adverse effects,  chemistry*
Biological Assay
Boric Acids / adverse effects,  chemistry*
Drug Interactions
Escherichia coli / drug effects*,  enzymology
Flavoring Agents / adverse effects
Food Additives
Food Coloring Agents / adverse effects
Food Contamination
Humans
Mutagenicity Tests
Mutagens / adverse effects,  chemistry*
beta-Galactosidase / biosynthesis
Chemical
Reg. No./Substance:
0/Boric Acids; 0/Flavoring Agents; 0/Food Additives; 0/Food Coloring Agents; 0/Mutagens; 11113-50-1/boric acid; 1162-65-8/Aflatoxin B1; EC 3.2.1.23/beta-Galactosidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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