Document Detail

Individual changes in lamotrigine plasma concentrations during pregnancy.
MedLine Citation:
PMID:  16084694     Owner:  NLM     Status:  MEDLINE    
Eleven pregnant women on lamotrigine (LTG) monotherapy were retrospectively reviewed. A significant decrease in the ratio of plasma LTG concentration-to-dose by 65.1% was observed during the second trimester (TM2) (p=0.0058) and by 65.8% during TM3 (p=0.0045) compared to pre-pregnancy values. Five patients experienced seizure deterioration during pregnancy. The pharmacokinetic changes display marked inter-patient variation, which stresses the importance of evaluating each woman individually by closely monitoring LTG concentrations until term.
Vaiva Petrenaite; Anne Sabers; Jacob Hansen-Schwartz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Epilepsy research     Volume:  65     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-08-22     Completed Date:  2005-11-29     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  185-8     Citation Subset:  IM    
Department of Clinical Neurophysiology 3063, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
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MeSH Terms
Anticonvulsants / blood*,  therapeutic use
Epilepsy / blood*,  drug therapy
Postpartum Period / blood,  drug effects
Pregnancy / blood*,  drug effects
Retrospective Studies
Triazines / blood*,  therapeutic use
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; U3H27498KS/lamotrigine

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