| Individual, but not simultaneous, glucagon and cholecystokinin infusions inhibit feeding in men. | |
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MedLine Citation:
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PMID: 1621876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pancreatic glucagon and cholecystokinin octapeptide (CCK-8) were intravenously infused (1 ml/min for 10 min) alone or in combination beginning 15 min after normal-weight men had eaten a 500-ml tomato soup preload and 5 min before they were served a lunch of macaroni and beef with tomato sauce. Infusion of approximately 3 ng.kg-1.min-1 glucagon or approximately 2 ng.kg-1.min-1 CCK-8 each reduced test meal size. However, simultaneous infusion of these peptide doses reduced meal size less than the sum of the peptides' individual effects. Infusions of approximately 1.5 ng.kg-1.min-1 glucagon or approximately 1 ng.kg-1.min-1 CCK-8 had neither individual nor interactive effects on meal size. Psychophysical ratings failed to detect nonspecific side effects after any of the infusions. That exogenous glucagon and CCK-8 each reduced meal size without side effects suggests that these peptides may participate in the physiological control of human appetite; that their simultaneous infusion resulted in an infra-additive reduction in meal size suggests that they can interact antagonistically. |
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Authors:
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N Geary; H R Kissileff; F X Pi-Sunyer; V Hinton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 262 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-08-04 Completed Date: 1992-08-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R975-80 Citation Subset: IM |
Affiliation:
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Department of Psychology, Columbia University, New York, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analysis of Variance Eating / drug effects* Glucagon / antagonists & inhibitors, pharmacology* Humans Infusions, Intravenous Male Self Concept Sincalide / antagonists & inhibitors, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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DK-26687/DK/NIDDK NIH HHS; DK-32448/DK/NIDDK NIH HHS; DK-36507/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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25126-32-3/Sincalide; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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