Document Detail


Individual variation in the motivational properties of cocaine.
MedLine Citation:
PMID:  21471956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cues in the environment associated with drug use draw the attention of addicts, elicit approach, and motivate drug-seeking and drug-taking behavior, making abstinence difficult. However, preclinical studies have identified large individual differences in the extent to which reward cues acquire these incentive motivational properties. For example, only in some rats does a spatially discrete food cue become attractive, eliciting approach and engagement with it, and acts as an effective conditioned reinforcer. Moreover, a discrete cocaine cue also acquires greater motivational control over behavior in rats prone to attribute incentive salience to a food cue. In this study, we asked whether there is similar individual variation in the extent to which interoceptive cues produced by cocaine itself instigate cocaine-seeking behavior. After quantifying individual variation in the propensity to attribute incentive salience to a food cue, rats were trained to self-administer cocaine in the absence of an explicit conditional stimulus. We then assessed motivation for cocaine by: (1) performance on a progressive ratio schedule, and (2) the degree to which a cocaine 'prime' reinstated cocaine-seeking following extinction of self-administration behavior. We found that rats prone to attribute incentive salience to a food cue worked harder for cocaine, and showed more robust cocaine-induced reinstatement. We conclude that there is considerable individual variation in the motivational properties of cocaine itself, and this can be predicted by the propensity to attribute incentive salience to reward cues.
Authors:
Benjamin T Saunders; Terry E Robinson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-04-06
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  36     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-15     Completed Date:  2012-03-22     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1668-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Addictive / genetics*,  psychology*
Cocaine / administration & dosage*
Individuality*
Male
Motivation / physiology*
Rats
Rats, Sprague-Dawley
Self Administration
Grant Support
ID/Acronym/Agency:
R37 DA004294/DA/NIDA NIH HHS; R37 DA004294-23/DA/NIDA NIH HHS; R37 DA04294/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
I5Y540LHVR/Cocaine
Comments/Corrections

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