Document Detail


Individual and network factors associated with prevalent hepatitis C infection among rural Appalachian injection drug users.
MedLine Citation:
PMID:  23153148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We determined the factors associated with hepatitis C (HCV) infection among rural Appalachian drug users.
METHODS: This study included 394 injection drug users (IDUs) participating in a study of social networks and infectious disease risk in Appalachian Kentucky. Trained staff conducted HCV, HIV, and herpes simplex-2 virus (HSV-2) testing, and an interviewer-administered questionnaire measured self-reported risk behaviors and sociometric network characteristics.
RESULTS: The prevalence of HCV infection was 54.6% among rural IDUs. Lifetime factors independently associated with HCV infection included HSV-2, injecting for 5 or more years, posttraumatic stress disorder, injection of cocaine, and injection of prescription opioids. Recent (past-6-month) correlates of HCV infection included sharing of syringes (adjusted odds ratio = 2.24; 95% confidence interval = 1.32, 3.82) and greater levels of eigenvector centrality in the drug network.
CONCLUSIONS: One factor emerged that was potentially unique to rural IDUs: the association between injection of prescription opioids and HCV infection. Therefore, preventing transition to injection, especially among prescription opioid users, may curb transmission, as will increased access to opioid maintenance treatment, novel treatments for cocaine dependence, and syringe exchange.
Authors:
Jennifer R Havens; Michelle R Lofwall; Simon D W Frost; Carrie B Oser; Carl G Leukefeld; Richard A Crosby
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-15
Journal Detail:
Title:  American journal of public health     Volume:  103     ISSN:  1541-0048     ISO Abbreviation:  Am J Public Health     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-02-21     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  1254074     Medline TA:  Am J Public Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e44-52     Citation Subset:  AIM; IM    
Affiliation:
Center on Drug and Alcohol Research, Department of Behavioral Science, University of Kentucky College of Medicine, Lexington, KY 40504, USA. jennifer.havens@uky.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Appalachian Region / epidemiology
Cocaine-Related Disorders
Cohort Studies
Female
HIV Infections / epidemiology
Hepatitis C / epidemiology*
Herpes Simplex / epidemiology
Humans
Kentucky / epidemiology
Male
Needle Sharing / statistics & numerical data
Opioid-Related Disorders*
Prevalence
Questionnaires
Risk Factors
Risk-Taking
Rural Population / statistics & numerical data*
Substance Abuse, Intravenous / epidemiology*
Grant Support
ID/Acronym/Agency:
R01 DA024598/DA/NIDA NIH HHS; R01DA024598/DA/NIDA NIH HHS; R03 DA024998/DA/NIDA NIH HHS; R03DA24998/DA/NIDA NIH HHS; R21 NR010961/NR/NINR NIH HHS; R21NR10961/NR/NINR NIH HHS
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