| Individual Classification of Mild Cognitive Impairment Subtypes by Support Vector Machine Analysis of White Matter DTI. | |
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MedLine Citation:
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PMID: 22976235 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE:MCI was recently subdivided into sd-aMCI, sd-fMCI, and md-aMCI. The current investigation aimed to discriminate between MCI subtypes by using DTI.MATERIALS AND METHODS:Sixty-six prospective participants were included: 18 with sd-aMCI, 13 with sd-fMCI, and 35 with md-aMCI. Statistics included group comparisons using TBSS and individual classification using SVMs.RESULTS:The group-level analysis revealed a decrease in FA in md-aMCI versus sd-aMCI in an extensive bilateral, right-dominant network, and a more pronounced reduction of FA in md-aMCI compared with sd-fMCI in right inferior fronto-occipital fasciculus and inferior longitudinal fasciculus. The comparison between sd-fMCI and sd-aMCI, as well as the analysis of the other diffusion parameters, yielded no significant group differences. The individual-level SVM analysis provided discrimination between the MCI subtypes with accuracies around 97%. The major limitation is the relatively small number of cases of MCI.CONCLUSIONS:Our data show that, at the group level, the md-aMCI subgroup has the most pronounced damage in white matter integrity. Individually, SVM analysis of white matter FA provided highly accurate classification of MCI subtypes. |
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Authors:
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S Haller; P Missonnier; F R Herrmann; C Rodriguez; M-P Deiber; D Nguyen; G Gold; K-O Lovblad; P Giannakopoulos |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-13 |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: - ISSN: 1936-959X ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Service neuro-diagnostique et neuro-interventionnel DISIM, Division of General Psychiatry, Division of Neuropsychiatry and Department of Internal Medicine, Rehabilitation, and Geriatrics, University Hospitals of Geneva, Geneva, Switzerland; INSERM U1039, Faculty of Medicine, La Tronche, France; Centre Diagnostic Radiologique Carouge, Carouge, Switzerland; and Division of Old Age Psychiatry, University of Lausanne School of Medicine, Lausanne, Switzerland. |
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