Document Detail


Individual classification of mild cognitive impairment subtypes by support vector machine analysis of white matter DTI.
MedLine Citation:
PMID:  22976235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: MCI was recently subdivided into sd-aMCI, sd-fMCI, and md-aMCI. The current investigation aimed to discriminate between MCI subtypes by using DTI.
MATERIALS AND METHODS: Sixty-six prospective participants were included: 18 with sd-aMCI, 13 with sd-fMCI, and 35 with md-aMCI. Statistics included group comparisons using TBSS and individual classification using SVMs.
RESULTS: The group-level analysis revealed a decrease in FA in md-aMCI versus sd-aMCI in an extensive bilateral, right-dominant network, and a more pronounced reduction of FA in md-aMCI compared with sd-fMCI in right inferior fronto-occipital fasciculus and inferior longitudinal fasciculus. The comparison between sd-fMCI and sd-aMCI, as well as the analysis of the other diffusion parameters, yielded no significant group differences. The individual-level SVM analysis provided discrimination between the MCI subtypes with accuracies around 97%. The major limitation is the relatively small number of cases of MCI.
CONCLUSIONS: Our data show that, at the group level, the md-aMCI subgroup has the most pronounced damage in white matter integrity. Individually, SVM analysis of white matter FA provided highly accurate classification of MCI subtypes.
Authors:
S Haller; P Missonnier; F R Herrmann; C Rodriguez; M-P Deiber; D Nguyen; G Gold; K-O Lovblad; P Giannakopoulos
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-13
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  34     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-08-06     Revised Date:  2013-10-22    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-91     Citation Subset:  IM    
Affiliation:
Service neuro-diagnostique et neuro-interventionnel DISIM, Hôpitaux Universitaires de Genève, Rue GabriellePerret-Gentil 4, 1211 Genève 14, Switzerland. sven.haller@hcuge.ch
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MeSH Terms
Descriptor/Qualifier:
Aged
Amnesia / classification,  diagnosis
Anisotropy
Diagnosis, Differential
Diffusion Tensor Imaging / methods*
Female
Humans
Leukoencephalopathies / classification,  diagnosis
Male
Middle Aged
Mild Cognitive Impairment / classification*,  diagnosis*
Nerve Fibers, Myelinated / pathology*
Neuropsychological Tests
Prospective Studies
Support Vector Machines*
Comments/Corrections
Comment In:
AJNR Am J Neuroradiol. 2013 Sep;34(9):E108-9
AJNR Am J Neuroradiol. 2013 Sep;34(9):E107   [PMID:  23868167 ]

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