| Indium-111 monoclonal antimyosin cardiac scintigraphy in suspected acute myocarditis: evolution and diagnostic impact. | |
| | |
MedLine Citation:
|
PMID: 12957757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: This study examined the evolution of the heart to lung (H/L) ratio of monoclonal antimyosin antibody (MAA) uptake in patients with suspected acute myocarditis (AM) and its time-dependent diagnostic value in conjunction with echocardiographic findings. METHODS: The study included 20 patients with a short history (<4 months) of heart failure symptoms and normal coronary arteries. All patients underwent cardiac antimyosin scintigraphy, echocardiography, right-heart catheterization and endomyocardial biopsy. Patients who survived beyond 1 year were reevaluated with a cardiac antimyosin scintigraphy and an echocardiographic study. RESULTS: Endomyocardial biopsy in 8/20 patients revealed findings compatible with the diagnosis of idiopathic dilated cardiomyopathy (group I) and in the remaining 12/20 was diagnostic of AM (group II). At baseline evaluation of the antimyosin H/L ratio uptake was similar in groups I and II, at 1.95+/-0.19 and 2.16+/-0.51, respectively (P=0.222), while the left ventricular end diastolic diameter (LVEDd) was significantly higher in group I (68+/-12 mm) than in group II (56+/-11 mm, P=0.041). In these patients an initial positive MAA scintigraphy (H/L ratio>1.55) associated with an LVEDd<or=62 mm was diagnostic of AM with a sensitivity of 67%, a specificity of 63% and a positive predictive value of 65%. Upon restudy, the H/L ratio of MAA uptake was significantly decreased in both groups, reaching almost identical levels. No difference was found in the LVEDd between the two groups. The positivity of cardiac antimyosin scintigraphy in conjunction with an LVEDd<or=62 mm had a sensitivity of 45% and a specificity of 88% for the diagnosis of myocarditis. CONCLUSIONS: In patients with suspected AM a positive antimyosin scintigraphy accompanied by a non-dilated left ventricle is highly suggestive of AM, both at the early phase and 1 year after disease onset. |
| | |
Authors:
|
Zafiria J Margari; Maria I Anastasiou-Nana; John Terrovitis; Savas Toumanidis; Emmanuel V Agapitos; John P Lekakis; John N Nanas |
Related Documents
:
|
12839087 - Therapeutic role of pericardiocentesis for acute necrotizing eosinophilic myocarditis w... 2805327 - Lymphocytic myocarditis and dilated cardiomyopathy: treatment with immunosuppressive ag... 11316137 - Recurrence of myocarditis presenting as pacing and sensing failure after implantation o... 20637387 - Postural hypotension as the initial presentation of fulminant right ventricular myocard... 22141747 - Right-left digit ratio (2d:4d) and maximal oxygen uptake. 23547937 - Myocardial protection against global ischemia with krebs-henseleit buffer-based cardiop... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of cardiology Volume: 90 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2003 Aug |
Date Detail:
|
Created Date: 2003-09-05 Completed Date: 2003-12-09 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 239-45 Citation Subset: IM |
Affiliation:
|
University of Athens School of Medicine, Department of Clinical Therapeutics, 'Alexandra' Hospital, Athens, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Adult Antibodies, Monoclonal / diagnostic use* Echocardiography Female Humans Indium Radioisotopes / diagnostic use* Male Myocarditis / immunology, radionuclide imaging*, ultrasonography Myosins / immunology* Sensitivity and Specificity Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Monoclonal; 0/Indium Radioisotopes; EC 3.6.4.1/Myosins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adeno-associated virus (AAV) vectors achieve prolonged transgene expression in mouse myocardium and ...
Next Document: Reciprocal activation of leukocyte-endothelial adhesion molecules in acute coronary syndromes.