Document Detail

Indisputable double paternity in dizygous twins.
MedLine Citation:
PMID:  9176461     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a case of heteropaternal superfecundation. DESIGN: Case report. SETTING: University paternity laboratory. PATIENT(S): Father, mother, and a set of twins. INTERVENTION(S): Blood typing conventional markers, as well as polymerase chain reaction loci and restriction fragment length polymorphism loci of DNA. MAIN OUTCOME MEASURE(S): Heteropaternal superfecundation was demonstrated after paternity investigation. RESULT(S): The probability of paternity for twin 1 was 99.9999998%, whereas that for twin 2 was excluded on the basis of the following tests: Fy, Pi, human leukocyte antigen (HLA)-DQA1, D1S80, D17S5, HBGG, D5S110, D2S44, and D10S28. CONCLUSION(S): Dizygous twins can have different biologic fathers, as demonstrated in this case. According to published data, the frequency of twins with different fathers is probably underestimated, at least in small selected populations such as those of paternity suits.
E Girela; J A Lorente; J C Alvarez; M D Rodrigo; M Lorente; E Villanueva
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  67     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-06-26     Completed Date:  1997-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1159-61     Citation Subset:  IM    
Department of Legal Medicine, Faculty of Medicine, University of Granada, Spain. EGIRELA@GOLIAT.UGR.ES
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MeSH Terms
Blood Grouping and Crossmatching
DNA / analysis*
Genetic Markers*
HLA-DQ Antigens / genetics
Infant, Newborn
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Twins, Dizygotic*
Reg. No./Substance:
0/Genetic Markers; 0/HLA-DQ Antigens; 0/HLA-DQA1; 9007-49-2/DNA

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