Document Detail


Indirubin inhibits tumor growth by anti-tumor angiogenesis through blocking VEGFR2 mediated JAK/STAT3 signaling in endothelial cell.
MedLine Citation:
PMID:  21207415     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Tumor angiogenesis is one of the hallmarks of the development in malignant neoplasias and metastasis. Many angiogenesis inhibitors are small molecules from natural products. Indirubin, the active component of a traditional Chinese herbal medicine, Banlangen, has been shown to exhibit antitumor and anti-inflammation effects. But its roles in tumor angiogenesis, the key step involved in tumor growth and metastasis, and the involved molecular mechanism is unknown. Here, we identified that indirubin inhibited prostate tumor growth through inhibiting tumor angiogenesis. Using chick chorioallantoic membrane (CAM) assay and mouse corneal model, we found that indirubin inhibited angiogenesis in vivo. We also showed the inhibition activity of indirubin in endothelial cell migration, tube formation and cell survival in vitro. Furthermore, indirubin suppressed VEGFR2 mediated JAK/STAT3 signaling pathway but had little effects on the activity of ERK and p38MAPK in endothelial cell. Our study provided the first evidence for anti-tumor angiogenesis activity of indirubin and the relateded molecular mechanism. Our investigations suggested that indirubin was a potential drug candidate for angiogenesis related diseases.
Authors:
Xiaoli Zhang; Yajuan Song; Yuanyuan Wu; Yanmin Dong; Li Lai; Jing Zhang; Binbin Lu; Fujun Dai; Lijun He; Mingyao Liu; Zhengfang Yi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-4
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
nstitute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
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