| Indirect stimulation by thyrotropin-releasing hormone of canine gallbladder motility. | |
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MedLine Citation:
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PMID: 3090395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thyrotropin-releasing hormone (TRH) was unable to induce any noticeable contraction of canine isolated gallbladder strips up to the dose of 10(-4) g/ml, while caerulein (CAER) was spasmogenic in a dose-related manner beyond 10(-11) g/ml. This effect of CAER was unaffected by either atropine or tetrodotoxin. In conscious dogs, the intravenous bolus of TRH (20 micrograms/kg) or CAER (0.2-2.0 micrograms/kg) caused gallbladder emptying. The TRH response, unlike that of an equipotent dose of CAER, was prevented by atropine. In experiments on electrical activity of the digestive tract in conscious dogs, both TRH or CAER induced a concomitant increase on the myoelectrical activity in the proximal part of the small intestine. The excitatory effects were prevented by atropine only in the case of TRH. These results demonstrate that TRH stimulates indirectly the gallbladder and proximal duodenum of the dog. They suggest the involvement of a cholinergic pathway in this excitatory action. |
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Authors:
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G Soldani; M Del Tacca; E Martino; C Bernardini; C Malbert |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 39 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1986 Aug |
Date Detail:
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Created Date: 1986-09-17 Completed Date: 1986-09-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 595-601 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Atropine / pharmacology Caerulein / pharmacology Dogs Dose-Response Relationship, Drug Female Gallbladder / drug effects* Gastrointestinal Motility / drug effects Intestine, Small / drug effects Male Muscle Contraction / drug effects Tetrodotoxin / pharmacology Thyrotropin-Releasing Hormone / pharmacology* |
| Chemical | |
Reg. No./Substance:
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17650-98-5/Caerulein; 24305-27-9/Thyrotropin-Releasing Hormone; 4368-28-9/Tetrodotoxin; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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