Document Detail

Indirect stimulation by thyrotropin-releasing hormone of canine gallbladder motility.
MedLine Citation:
PMID:  3090395     Owner:  NLM     Status:  MEDLINE    
Thyrotropin-releasing hormone (TRH) was unable to induce any noticeable contraction of canine isolated gallbladder strips up to the dose of 10(-4) g/ml, while caerulein (CAER) was spasmogenic in a dose-related manner beyond 10(-11) g/ml. This effect of CAER was unaffected by either atropine or tetrodotoxin. In conscious dogs, the intravenous bolus of TRH (20 micrograms/kg) or CAER (0.2-2.0 micrograms/kg) caused gallbladder emptying. The TRH response, unlike that of an equipotent dose of CAER, was prevented by atropine. In experiments on electrical activity of the digestive tract in conscious dogs, both TRH or CAER induced a concomitant increase on the myoelectrical activity in the proximal part of the small intestine. The excitatory effects were prevented by atropine only in the case of TRH. These results demonstrate that TRH stimulates indirectly the gallbladder and proximal duodenum of the dog. They suggest the involvement of a cholinergic pathway in this excitatory action.
G Soldani; M Del Tacca; E Martino; C Bernardini; C Malbert
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  39     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  595-601     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Atropine / pharmacology
Caerulein / pharmacology
Dose-Response Relationship, Drug
Gallbladder / drug effects*
Gastrointestinal Motility / drug effects
Intestine, Small / drug effects
Muscle Contraction / drug effects
Tetrodotoxin / pharmacology
Thyrotropin-Releasing Hormone / pharmacology*
Reg. No./Substance:
17650-98-5/Caerulein; 24305-27-9/Thyrotropin-Releasing Hormone; 4368-28-9/Tetrodotoxin; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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