| Indirect blue light does not suppress nocturnal salivary melatonin in humans in an automobile setting. | |
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MedLine Citation:
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PMID: 19555449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 2007, the International Agency for Research on Cancer (IARC) classified shift work that involves circadian disruption as being probably carcinogenic to humans (Group 2A). In this context, light exposure during the night plays a key role because it can suppress nocturnal melatonin levels when exposures exceed a certain threshold. Blue light around 464 nm is most effective in suppressing melatonin because of the spectral sensitivity of melanopsin, a recently discovered photopigment in retinal ganglion cells; the axons of these cells project to the suprachiasmatic nucleus, a circadian master clock in the brain. Due to advances in light technologies, normal tungsten light bulbs are being replaced by light-emitting diodes which produce quasi-monochromatic or white light. The objective of this study was to assess whether the light-melanopsin-melatonin axis might be affected in automobiles at night which employ the new generation diodes. To this end, we have tested in an experimental automobile setting whether indirect blue light (lambda(max) = 465 nm) at an intensity of 0.22 or 1.25 lx can suppress salivary melatonin levels in 12 male volunteers (age range 17-27 years) who served as their own controls. Daytime levels were low (2.7 +/- 0.5 pg/mL), and night-time levels without light exposure were high (14.5 +/- 1.1 pg/mL), as expected. Low-intensity light exposures had no significant effect on melatonin levels (0.22 lx: 17.2 +/- 2.8 pg/mL; P > 0.05; 1.25 lx: 12.6 +/- 2.0 pg/mL; P > 0.05). It is concluded that indirect blue light exposures in automobiles up to 1.25 lx do not cause unintentional chronodisruption via melatonin suppression. |
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Authors:
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Alexander Lerchl; Carina Schindler; Karsten Eichhorn; Franziska Kley; Thomas C Erren |
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Publication Detail:
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Type: Journal Article Date: 2009-06-23 |
Journal Detail:
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Title: Journal of pineal research Volume: 47 ISSN: 1600-079X ISO Abbreviation: J. Pineal Res. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-19 Completed Date: 2009-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8504412 Medline TA: J Pineal Res Country: Denmark |
Other Details:
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Languages: eng Pagination: 143-6 Citation Subset: IM |
Affiliation:
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School of Engineering and Science, Jacobs University, D-28759 Bremen, Germany. a.lerchl@jacobs-university.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Automobiles* Circadian Rhythm / physiology Humans Lighting* Male Melatonin / metabolism, secretion* Salivary Glands / secretion* Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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